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CAS No 63394-05-8 , 2-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)
propanamide

  • Name: 2-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)
    propanamide
  • Synonyms: Idonor; Plafibridum [INN-Latin];2-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)
    propanamide;Perifunal; Ita 104; Plafibrida [INN-Spanish]; EINECS 264-121-2; BRN 0569805; ITA-104; Plafibrida [Spanish];
  • CAS Registry Number:
  • Density: 1.251g/cm3
  • Refractive index: 1.544
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. Used as an antithrombotic agent. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
  • EINECS: 264-121-2
  • Molecular Weight: 355.81658
  • InchiKey: DDDQVDIPBFGVIG-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H22ClN3O4/c1-16(2,
    24-13-5-3-12(17)4-6-13)14(21)19-15(22)18-11-20-7-9-23-10-8-20/h3-6H,
    7-11H2,1-2H3,(H2,18,19,21,22)
  • Molecular Formula: C16H22ClN3O4
  • Molecular Structure:CAS No:63394-05-8 2-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)<br />propanamide

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63394-05-8 PLAFIBRIDE

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References of 2-(4-chlorophenoxy)-2-methyl-N-(morpholin-4-ylmethylcarbamoyl)
propanamide
Title: Plafibride
CAS Registry Number: 63394-05-8
CAS Name: 2-(4-Chlorophenoxy)-2-methyl-N-[[(4-morpholinylmethyl)amino]carbonyl]propanamide
Synonyms: N-2-(p-chlorophenoxy)isobutyryl-N￠-morpholinomethylurea
Manufacturers' Codes: ITA-104
Trademarks: Idonor (Roger); Perifunal (Aristegui)
Molecular Formula: C16H22ClN3O4
Molecular Weight: 355.82
Percent Composition: C 54.01%, H 6.23%, Cl 9.96%, N 11.81%, O 17.99%
Literature References: Analog of clofibrate, q.v. Prepn: J. Iniesta-Pons, DE 2716374 (1977 to Investigacion Tecnica y Aplicada), C.A. 88, 37810g (1978). Toxicity data: J. Zapatero, L. Brugeghini, Arch. Farmacol. Toxicol. 4, 137 (1978). Series of articles on antiplatelet aggregation activity, hypolipemic activity, pharmacology, and toxicology: ibid., 132-142.
Properties: Crystals, mp 100-102°. Sol in acetone. Slightly sol in alcohol. Practically insol in water, petr ether. LD50 in mice, rats, guinea pigs (mg/kg): 3569, >4000, 2168 orally (Zapatero, Brugeghini).
Melting point: mp 100-102°
Toxicity data: LD50 in mice, rats, guinea pigs (mg/kg): 3569, >4000, 2168 orally (Zapatero, Brugeghini)
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.