Home > Name List By other > (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

CAS No 61869-08-7 , (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

  • Name: (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
  • Synonyms: Frosinor;Paxil; Paroxetina [INN-Spanish]; Aropax;(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine; Paroxetinum [INN-Latin]; Pexeva; Paroxetinum; Paxil CR; Seroxat;
  • CAS Registry Number:
  • Transport: 3249
  • Density: 1.213 g/cm3
  • Refractive index: 1.561
  • Water Solubility: SOLVENT
  • Hazard Symbols: UN NO.
  • Molecular Weight: 329.365403
  • InchiKey: AHOUBRCZNHFOSL-YOEHRIQHSA-N
  • InChI: InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-
    6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1
  • Molecular Formula: C19H20FNO3
  • Molecular Structure:CAS No:61869-08-7 (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine

Related products

Search by region :

Select to

61869-08-7 (3S)-TRANS-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE

  • China Rongkang industry Co.,Ltd [Manufacturer]
  • Tel: +86-571-8801 0713
  • Fax: +86-571-8801 0679
  • Address: Rongkang Industry Co.,Ltd
    2-3-1502 XIANGXIELI GARDEN
    NO.4 STREET XIASHA
    HANGZHOU, CHINA P.C:310018 null,nullChina
Contact Supplier

61869-08-7 Paroxetine

  • China TaiZhou HiKong Chemical Co., Ltd. null
  • Tel: +86-18967213045,13957694715
  • Fax: +86-(580)-6033180,6034626
  • Address: Taizhou Economic Technical Development Zone, Taizhou, Zhejiang 318000, null,nullChina
Contact Supplier

61869-08-7 PAROXETINE

  • United States NetQem, LLC [Manufacturer]
  • Tel: (919) 544-4122
  • Fax: (919) 544-4109
  • Address: NetQem, LLC
    P.O. Box 12091
    Research Triangle Park
    NC 27709, USA null,nullUnited States
Contact Supplier

61869-08-7 (3S)-TRANS-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE

  • China Leap Labchem Co.,Ltd [Manufacturer]
  • Tel: +86-571-87756549
  • Fax: +86-571-87755464
  • Address: Leap Labchem Co.,Ltd
    Zhongtian Mansion,No.173,
    Yugu Road Xihu District,
    Hangzhou,310007,PR,China null,nullChina
Contact Supplier

61869-08-7 Paroxetine HCl

  • United States Tecoland Corporation null
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, null,nullUnited States
Contact Supplier

61869-08-7 Paroxetine HCl

  • China Leap Labchem Co.Ltd [Manufacturer]
  • Tel: +86-571-87756549
  • Fax: +86-571-87755464
  • Address: Leap Labchem Co.,Ltd
    Zhongtian Mansion,No.173,
    Yugu Road Xihu District,
    Hangzhou,310007,PR,China null,nullChina
Contact Supplier

61869-08-7 Paroxetine hydrochloride

  • Paroxetine hydrochloride
  • United States LKT Laboratories, Inc [Manufacturer]
  • Tel: (888)-558-5227
  • Fax:
  • Address: 2233 University Ave. West 55114-1600 St. PaulUNITED STATES 55114-1600 St. Paul,nullUnited States
Contact Supplier

61869-08-7 Paroxetine HCL

  • Paroxetine HCL
  • India J.INC. [Manufacturer]
  • Tel: +91 79 30071152, 30071190, 30071175, 30071153
  • Fax: +91 79 30071176, 26574630
  • Address: # 95, Rangwala Towers, Law garden, Ellisbridge, Ahmedabad 380006, Gujarat State, India. 380006 AhmedabadINDIA Ahmedabad,nullIndia
Contact Supplier

61869-08-7 Paroxetine base

  • Paroxetine base
  • China Hangzhou Pharma & Chem Co., Ltd. [Manufacturer]
  • Tel: +86 571 87040515
  • Fax: +86 571 87214761
  • Address: Hangzhou Pharma & Chem Co., Ltd.
    139 Qingchun Road, Hangzhou City,
    Zhejiang, China 310003 null,nullChina
Contact Supplier

61869-08-7 Paroxetine

  • Hong kong LEO CHEMICAL (HONG KONG) CO., LTD [Manufacturer]
  • Tel: 86-519-85098858/ 86-519-85098877
  • Fax: 86-519-85098888/8889
  • Address: Hong Kong Office :
    LEO CHEMICAL (HONG KONG) CO., LTD
    MNJ2070, RM1602,
    OMEGA PLAZA, 32 DUNDAS STREET,
    MONKOK, KL, HONG KONG null,nullHong kong
Contact Supplier

Select to

3/9
Previous 1 2 3 4 5 6 7 8 9 Next
References of (3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
Title: Paroxetine
CAS Registry Number: 61869-08-7
CAS Name: (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
Synonyms: (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]piperidine
Manufacturers' Codes: FG-7051; BRL-29060
Molecular Formula: C19H20FNO3
Molecular Weight: 329.37
Percent Composition: C 69.28%, H 6.12%, F 5.77%, N 4.25%, O 14.57%
Literature References: Selective serotonin (5-HT) reuptake inhibitor (SSRI). Prepn: J. A. Christensen, R. F. Squires, DE 2404113; eidem, US 3912743; US 4007196 (1974, 1975, 1977 all to Ferrosan); of crystalline hydrochloride hemihydrate: R. D. B. Barnes et al., EP 223403; US 4721723 (1987, 1988 both to Beecham). Characterization of serotonin inhibition: J. Buus Lassen, Eur. J. Pharmacol. 47, 351 (1978). Binding to serotonin transporter complex: E. Habert et al., ibid. 118, 107 (1985). Clinical pharmacokinetics: J. Lund et al., Acta Pharmacol. Toxicol. 51, 351 (1982). HPLC determn in plasma: M. A. Brett et al., J. Chromatogr. 419, 438 (1987). Clinical trial in obsessive-compulsive disorder: J. Zohar et al., Br. J. Psychiatry 169, 468 (1996); in social phobia: M. B. Stein et al., J. Am. Med. Assoc. 280, 708 (1998). Review of pharmacology and clinical use in depression: K. L. Dechant, S. P. Clissold, Drugs 41, 225-253 (1991); of clinical experience: D. Dunner, R. Kumar, Pharmacopsychiatry 31, 89-101 (1998); of use in generalized social anxiety disorder: M. Van Ameringen et al., Expert Opin. Pharmacother. 6, 819-830 (2005).
 
Derivative Type: Hydrochloride hemihydrate
CAS Registry Number: 110429-35-1; 78246-49-8 (hydrochloride)
Trademarks: Aropax (GSK); Deroxat (GSK); Paxil (GSK); Seroxat (GSK)
Molecular Formula: C19H20FNO3.HCl.?H2O
Molecular Weight: 374.83
Percent Composition: C 60.88%, H 5.92%, F 5.07%, N 3.74%, O 14.94%, Cl 9.46%
Properties: Crystals, mp 129-131°. Soly in water: 5.4 mg/ml.
Melting point: mp 129-131°
 
Derivative Type: Maleate
CAS Registry Number: 64006-44-6
Properties: Crystals from ethanol-ether, mp 136-138°. [a]D -87° (c = 5 in ethanol). LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977).
Melting point: mp 136-138°
Optical Rotation: [a]D -87° (c = 5 in ethanol)
Toxicity data: LD50 in mice (mg/kg): 845 s.c.; 500 orally (Christensen, Squires, 1977)
 
Therap-Cat: Antidepressant; antiobsessional.
Keywords: Antidepressant; Bicyclics; Serotonin Uptake Inhibitor; Antiobsessional.