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CAS No 61379-65-5 , Rifapentine Search by region : China

  • Name: Rifapentine
  • Synonyms: 3{[(4-Cyclopentyl-1-piperazinyl)imino]methyl}rifamycin;Rifapentine;
  • CAS Registry Number:
  • Transport: OTH
  • Melting Point: 179-1800C
  • Density: 1.35 g/cm3 (20 C)
  • Refractive index: 1.63
  • Water Solubility: slightly soluble
  • Hazard Symbols: UN NO.
  • EINECS: 262-743-9
  • Molecular Weight: 877.03
  • InChI: InChI=1/C47H64N4O12/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)/b13-12+,22-17+,25-14-,48-23+/t24-,26+,27-,28-,33+,38-,39-,43-,47+/m1/s1
  • Molecular Formula: C47H64N4O12
  • Molecular Structure:CAS No:61379-65-5 Rifapentine

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References of Rifapentine
Title: Rifapentine
CAS Registry Number: 61379-65-5
CAS Name: 3-[[(4-Cyclopentyl-1-piperazinyl)imino]methyl]rifamycin
Manufacturers' Codes: MDL-473; DL-473; R-773
Trademarks: Priftin (Aventis)
Molecular Formula: C47H64N4O12
Molecular Weight: 877.03
Percent Composition: C 64.37%, H 7.36%, N 6.39%, O 21.89%
Literature References: Semi-synthetic rifamycin. Prepn: R. Cricchio, V. Arioli, DE 2608218; eidem, US 4002752 (1976, 1977 both to Lepetit). Antibacterial activity: V. Arioli et al., J. Antibiot. 34, 1026 (1981); H. C. Neu, Antimicrob. Agents Chemother. 24, 457 (1983). Pharmacokinetics: A. Assandri et al., J. Antibiot. 37, 1066 (1984). HPLC determn in plasma: E. Riva et al., J. Chromatogr. 553, 35 (1991). Clinical trial in tuberculosis: Natl. Co-op Group Clin. Study Rifapentine, Chin. J. Antibiot. 17, 313 (1992), B.A. 95, 70840 (1993). Review of pharmacology and clinical efficacy: B. Jarvis, H. M. Lamb, Drugs 56, 607-616 (1998).
Properties: Crystals from ethyl acetate, mp 179-180°. uv max: 475, 334 nm (e 15200, 26700). LD50 in mice (mg/kg): >2000 orally; 750 i.p. (Cricchio). Also reported as LD50 in mice (mg/kg): 3300 orally; 710 i.p. (Aroli).
Melting point: mp 179-180°
Absorption maximum: uv max: 475, 334 nm (e 15200, 26700)
Toxicity data: LD50 in mice (mg/kg): >2000 orally; 750 i.p. (Cricchio); LD50 in mice (mg/kg): 3300 orally; 710 i.p. (Aroli)
Therap-Cat: Antibacterial (tuberculostatic).
Keywords: Antibacterial (Antibiotics); Ansamycins; Antibacterial (Tuberculostatic).