CAS No 60940-34-3 , 2-phenyl-1,2-benzoselenazol-3-one Search by region : Germany

Name: 2-phenyl-1,2-benzoselenazol-3-one
Synonyms: 2-phenyl-1,2-benzoselenazol-3-one; Harmokisane;2-Phenyl-1,2-benzisoselenazol-3(2H)-one; Ebselene; 60940-34-3; Ebselenum [Latin]; Ebselene [French]; Ebseleno [Spanish];
CAS Registry Number:60940-34-3
Transport: UN 3283
Melting Point: 178-181 ºC
Safety Statements: R23/25;R33;R50/53
Hazard Symbols: N: Dangerous for the environment;T: Toxic;
Molecular Weight: 274.17666
InchiKey: DYEFUKCXAQOFHX-UHFFFAOYSA-N
InChI: InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-
9H
Risk Statements: S20/21;S28A;S45;S60;S61
Molecular Formula: C₁₃H₉NOSe
Molecular Structure:

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           60940-34-3 EBSELEN
           
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           Ebselen
 
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References of 2-phenyl-1,2-benzoselenazol-3-one

Title: Ebselen
CAS Registry Number: 60940-34-3
CAS Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Manufacturers' Codes: PZ-51
Molecular Formula: C13H9NOSe
Molecular Weight: 274.18
Percent Composition: C 56.95%, H 3.31%, N 5.11%, O 5.84%, Se 28.80%
Literature References: Seleno-organic which shows antioxidant effects through glutathione peroxidase-like action. Prepn: R. Lesser, R. Weiss, Ber. 57, 1077 (1924); R. Weber, M. Renson, Bull. Soc. Chim. Fr. 1976, 1124; L. Engman, A. Hallberg, J. Org. Chem. 54, 2964 (1989). One-step synthesis: J. Oppenheimer, L. A. Silks, III, J. Labelled Compd. Radiopharm. 38, 281 (1996). HPLC determn in plasma: R. Terlinden et al., J. Chromatogr. 430, 438 (1988). Clinical trial as neuroprotectant in ischemic stroke: T. Yamaguchi et al., Stroke 29, 12 (1998); A. Ogawa et al., Cerebrovasc. Dis. 9, 112 (1999). Review of pharmacology: M. J. Parnham et al., 32, 4-9 (1991); and of biochemical interactions: T. Schewe, Gen. Pharmacol. 26, 1153-1169 (1995). Review as glutathione peroxidase mimic: H. Sies, Free Radical Biol. Med. 14, 313-323 (1993).
Properties: Crystals from ethanol, mp 180-181°.
Melting point: mp 180-181°