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CAS No 60731-46-6 , Elcatonin Search by region : China

  • Name: Elcatonin
  • Synonyms: EINECS 262-393-7;Carbocalcitonin; Elcatonina [INN-Spanish]; Elcatonine [INN-French]; HC-58; Elcatoninum [INN-Latin];Elcatonin;
  • CAS Registry Number:
  • Refractive index: 1.658
  • Safety Statements: A poison by ingestion, subcutaneous, intravenous, and intramuscular routes. When heated to decomposition it emits acrid smoke and irritating vapors.
  • Hazard Symbols: A poison by ingestion.
  • EINECS: 262-393-7
  • Molecular Weight: 3363.77416
  • InchiKey: JYSJVJJVLNYRKL-QPHHPWFVSA-N
  • InChI: InChI=1S/C148H244N42O47/c1-69(2)52-92(178-142(231)115(75(13)14)185-128
    (217)87-30-21-20-22-36-113(208)237-67-84(151)122(211)172-98(59-107(154)
    200)136(225)176-96(56-73(9)10)134(223)182-102(66-192)139(228)188-116(77
    (16)193)143(232)171-87)123(212)161-63-109(202)165-85(31-23-25-47-149)124
    (213)173-95(55-72(7)8)133(222)181-101(65-191)138(227)169-89(41-44-105
    (152)198)126(215)167-91(43-46-111(204)205)127(216)175-94(54-71(5)6)132
    (221)177-97(58-82-61-158-68-163-82)135(224)166-86(32-24-26-48-150)125
    (214)174-93(53-70(3)4)131(220)168-90(42-45-106(153)199)130(219)187-118
    (79(18)195)145(234)180-100(57-81-37-39-83(197)40-38-81)146(235)190-51-
    29-35-104(190)140(229)170-88(33-27-49-159-148(156)157)129(218)186-117(78
    (17)194)144(233)179-99(60-112(206)207)137(226)184-114(74(11)12)141(230)
    162-62-108(201)164-76(15)121(210)160-64-110(203)183-119(80(19)196)147
    (236)189-50-28-34-103(189)120(155)209/h37-40,61,68-80,84-104,114-119,
    191-197H,20-36,41-60,62-67,149-151H2,1-19H3,(H2,152,198)(H2,153,199)(H2,
    154,200)(H2,155,209)(H,158,163)(H,160,210)(H,161,212)(H,162,230)(H,164,
    201)(H,165,202)(H,166,224)(H,167,215)(H,168,220)(H,169,227)(H,170,
    229)(H,171,232)(H,172,211)(H,173,213)(H,174,214)(H,175,216)(H,176,
    225)(H,177,221)(H,178,231)(H,179,233)(H,180,234)(H,181,222)(H,182,
    223)(H,183,203)(H,184,226)(H,185,217)(H,186,218)(H,187,219)(H,188,
    228)(H,204,205)(H,206,207)(H4,156,157,159)/t76-,77+,78+,79+,80+,84-,85-,
    86-,87?,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,
    103-,104-,114-,115-,116-,117-,118-,119-/m0/s1
  • Molecular Formula: C148H244N42O47
  • Molecular Structure:CAS No:60731-46-6 Elcatonin

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    References of Elcatonin
    Title: Elcatonin
    CAS Registry Number: 60731-46-6
    CAS Name: 1-Butanoic acid 1,7-dicarbacalcitonin (eel)
    Synonyms: 1,4,7,10,13,16-hexaazacyclotricosane cyclic peptide deriv; [aminosuberic acid 1,7]-eel calcitonin; [ASU1,7]-ECT; carbocalcitonin
    Manufacturers' Codes: HC-58
    Trademarks: Calcinil (Sclavo); Elcitonin (Toyo Jozo); Turbocalcin (SKB)
    Molecular Formula: C148H244N42O47
    Molecular Weight: 3363.77
    Percent Composition: C 52.84%, H 7.31%, N 17.49%, O 22.36%
    Literature References: Synthetic analog of eel calcitonin in which the 1 and 7 cystine residues have been modified to deaminosuberic acid. Inhibits osteoclast bone resorption and induces uptake of calcium from body fluids. Prepn: S. Sakakibara et al., DE 2616399; eidem, US 4086221 (1976, 1978 both to Toyo Jozo); T. Morikawa et al., Experientia 32, 1104 (1976). Structural characterization: P. L. Mauri et al. Rapid Commun. Mass Spectrom. 11, 1292 (1997). Immunoassay determn in plasma: M. Takeyama et al. Biol. Pharm. Bull. 18, 900 (1995); HPLC determn in pharmaceutical prepn: K. Maekawa et al. Iyakuhin Kenkyu 32, 465 (2001). Mechanistic study: M. Ikegame et al., J. Bone Miner. Res. 9, 25 (1994). Clinical pharmacology: T. Ishioka, Pharmatherapeutica 1, 625 (1977); in Paget's disease patients: A. Caniggia et al., Minerva Med. 74, 993 (1983). Clinical trial in osteoporosis: Italian Osteoporosis Network, Curr. Ther. Res. 45, 502 (1989); in combination with alfacalcidol, q.v.: T. Fujita et al. J. Bone Miner. Metab. 15, 223 (1997).
    Therap-Cat: Calcium regulator. Treatment of Paget's disease.
    Keywords: Antipagetic; Calcium Regulator.