CAS No 60668-24-8 , 1-(2-aminopropanoylamino)ethylphosphonic acid

Name: 1-(2-aminopropanoylamino)ethylphosphonic acid
Synonyms: NSC-312628; CTK8G0479; N-D-Alanyl-1-aminoethylphosphonic acid; NSC312628; AG-G-20386;AC1L57EB; CHEMBL70855;1-(2-aminopropanoylamino)ethylphosphonic acid;
CAS Registry Number:60668-24-8
Density: 1.395g/cm³
Refractive index: 1.512
Hazard Symbols: Xn
EINECS: 262-362-8
Molecular Weight: 196.141482
InchiKey: BHAYDBSYOBONRV-UHFFFAOYSA-N
InChI: InChI=1S/C5H13N2O4P/c1-3(6)5(8)7-4(2)12(9,10)11/h3-4H,6H2,1-2H3,(H,7,
8)(H2,9,10,11)
Risk Statements: 22
Molecular Formula: C₅H₁₃N₂O₄P
Molecular Structure:

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References of 1-(2-aminopropanoylamino)ethylphosphonic acid

Title: Alafosfalin
CAS Registry Number: 60668-24-8
CAS Name: [(1R)-1-[[(2S)-2-Amino-1-oxopropyl]amino]ethyl]phosphonic acid
Synonyms: 1R-1-(L-alanylamino)ethylphosphonic acid; alaphosphin
Manufacturers' Codes: Ro-3-7008
Molecular Formula: C5H13N2O4P
Molecular Weight: 196.14
Percent Composition: C 30.62%, H 6.68%, N 14.28%, O 32.63%, P 15.79%
Literature References: Synthetic phosphonodipeptide with antibacterial activity. Prepn: F. R. Atherton et al., DE 2602193; eidem, US 4016148 (1976, 1977 both to Hoffmann-La Roche); J. G. Allen et al., Nature 272, 56 (1978); F. R. Atherton et al., Antimicrob. Agents Chemother. 15, 677 (1979). Improved process: E. K. Baylis, EP 10872; eidem, US 4331591 (1980, 1982 both to Ciba-Geigy). Separation of diastereoisomers: J. Szewczyk et al., Experientia 38, 983 (1982). Antibacterial spectrum: F. R. Atherton et al., Antimicrob. Agents Chemother. 15, 684 (1979); W. H. Traub, Chemotherapy 26, 103 (1980). Synergism with b-lactams: H. B. Maruyama et al., Antimicrob. Agents Chemother. 16, 444 (1979); F. R. Atherton et al., ibid. 20, 470 (1981); M. Arisawa et al., ibid. 21, 706 (1982). Pharmacokinetics: J. D. Allen, L. J. Lees, ibid. 17, 973 (1980). Comprehensive review: C. H. Hassall in Antibiotics VI, F. E. Hahn, Ed. (Springer-Verlag, New York, 1983) pp 1-11.
Properties: Crystals from ethanol-water, mp 295-296° (dec). [a]D20 -44.0° (c = 1 in H2O).
Melting point: mp 295-296° (dec)
Optical Rotation: [a]D20 -44.0° (c = 1 in H2O)