References of Frangulin (A : B approx. 4 : 1)
Title: Frangulin
CAS Registry Number: 60529-33-1
Synonyms: Franguloside; avornin
Trademarks: Cascarin
Literature References: In berries, bark, and rootbark of
Rhamnus spp., especially in alder buckthorn
(Rhamnus frangula L.),
Rhamnus carthartica L., and
Rhamnus purshiana DC. (
Cascara sagrada), Rhamnaceae. Prepn from bark of alder buckthorn: Bridel, Charaux,
Bull. Soc. Chim. Biol. 15, 642 (1933); M. Kubiak,
Herba Pol. 23, 217 (1977),
C.A. 88, 166260b (1978). Consists of the two glucosides, frangulins A and B, which were originally thought to be isomeric. Structure and synthesis of frangulin A: H?rhammer, Wagner,
Z. Naturforsch. 27B, 959 (1972). Structure of frangulin B: Wagner, Demuth,
Tetrahedron Lett. 1972, 5013.
Derivative Type: Frangulin A
CAS Registry Number: 521-62-0
Synonyms: 1,3,8-Trihydroxy-6-methylanthraquinone-
l-rhamnoside; emodin-
l-rhamnoside; rhamnoxanthin
Molecular Formula: C21H20O9
Molecular Weight: 416.38
Percent Composition: C 60.58%, H 4.84%, O 34.58%
Properties: Crystals, mp 228°. Absorption max: 225, 264, 282, 300, 430 nm (log e 4.52, 4.28, 4.15, 3.97, 4.05).
Melting point: mp 228°
Absorption maximum: Absorption max: 225, 264, 282, 300, 430 nm (log e 4.52, 4.28, 4.15, 3.97, 4.05)
Derivative Type: Frangulin B
CAS Registry Number: 14101-04-3
Synonyms: 6-
O-(D-Apiofuranosyl)-1,6,8-trihydroxy-3-methylanthraquinone
Molecular Formula: C20H18O9
Molecular Weight: 402.35
Percent Composition: C 59.70%, H 4.51%, O 35.79%
Properties: mp 196°.
Melting point: mp 196°
Therap-Cat: Cathartic.
Keywords: Laxative/Cathartic.