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CAS No 60-91-3 , 10H-Phenothiazine-10-ethanamine,N,N-diethyl-

  • Name: 10H-Phenothiazine-10-ethanamine,N,N-diethyl-
  • Synonyms: Diethazine; 10-(2-Diethylaminoethyl)phenothiazine; Eazamine; Ethylemin;10H-Phenothiazine-10-ethanamine,N,N-diethyl-;N-(2'-Diethylaminoethyl)dibenzoparathiazine; Dolisina; Eazaminum; RP 2987;N-(Diethylaminoethyl)thiodiphenylamine;Phenothiazine,10-[2-(diethylamino)ethyl]- (8CI); Parkazin;
  • CAS Registry Number:
  • Flash Point: 209.1°C
  • Boiling Point: 422.2°C at 760 mmHg
  • Density: 1.115g/cm3
  • Refractive index: 1.608
  • Safety Statements: Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx and SOx.
  • Flash Point: 209.1°C
  • EINECS: 200-491-3
  • Molecular Weight: 298.48
  • InChI: InChI=1/C18H22N2S/c1-3-19(4-2)13-14-20-15-9-5-7-11-17(15)21-18-12-8-6-10-16(18)20/h5-12H,3-4,13-14H2,1-2H3
  • Molecular Formula: C18H22 N2 S
  • Molecular Structure:CAS No:60-91-3 10H-Phenothiazine-10-ethanamine,N,N-diethyl-

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References of 10H-Phenothiazine-10-ethanamine,N,N-diethyl-
Title: Diethazine
CAS Registry Number: 60-91-3
CAS Name: N,N-Diethyl-10H-phenothiazine-10-ethanamine
Synonyms: 10-(2-diethylaminoethyl)phenothiazine; N-(diethylaminoethyl)thiodiphenylamine; N-(2￠-diethylaminoethyl)dibenzoparathiazine
Manufacturers' Codes: RP-2987
Trademarks: Deparkin; Dinezin; Dolisina; Eazaminum; Ethylemin; Parkazin
Molecular Formula: C18H22N2S
Molecular Weight: 298.45
Percent Composition: C 72.44%, H 7.43%, N 9.39%, S 10.74%
Literature References: Anticholinergic. Prepd by reacting 10-phenothiazineethyl chloride with diethylamine in presence of copper powder or by reacting diethylaminoethyl chloride with phenothiazine: Charpentier, Compt. Rend. 225, 306 (1947); Huttrer, Enzymologia 12, 293 (1948); Charpentier, US 2530451 (1950 to Rh?ne-Poulenc); Berg, Ashley, US 2607773 (1952 to Rh?ne-Poulenc). Toxicity study: Bovet et al., Therapie 2, 115 (1947).
Properties: Oily liquid. bp4-5 195-208°; bp0.4-0.5 167-175°.
Boiling point: bp4-5 195-208°; bp0.4-0.5 167-175°
 
Derivative Type: Hydrochloride
CAS Registry Number: 341-70-8
Trademarks: Antipar (Farmitalia); Aparkazin; Diparcol (Specia); Latibon (Bayer); Thiantan; Thiontan
Molecular Formula: C18H22N2S.HCl
Molecular Weight: 334.91
Percent Composition: C 64.55%, H 6.92%, N 8.36%, S 9.57%, Cl 10.59%
Properties: Crystals, mp 184-186°. Burning taste, producing a temporary numbness of the tongue. One part dissolves in about 5 parts water, 6 parts ethanol, 5 parts chloroform. Practically insol in ether. pH of 10% aq soln 5.0-5.3. LD50 orally in mice: 450 mg/kg (Bovet).
Melting point: mp 184-186°
Toxicity data: LD50 orally in mice: 450 mg/kg (Bovet)
 
Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Antimuscarinic.