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CAS No 60-40-2 , N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine

  • Name: N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine
  • Synonyms: Mecamilamina; Mekamine; 3-Methylaminoisocamphane; Revertina;Versamine; Mecamine; 2-Methylaminoisocamphane;N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine; Mevasine;
  • CAS Registry Number:
  • Flash Point: 58.1°C
  • Boiling Point: 189.3°C at 760 mmHg
  • Safety Statements: Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 58.1°C
  • EINECS: 200-476-1
  • Molecular Weight: 167.29114
  • InchiKey: IMYZQPCYWPFTAG-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3
  • Molecular Formula: C11H21N
  • Molecular Structure:CAS No:60-40-2 N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine

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60-40-2 Mecamylamine

  • IUPAC NAME-(1S,2R,4R)-N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine MOLECULAR FORMULA-C11H21N MOLAR MASS-167.291 g/mol Mecamylamine has been used as an orally-active ganglionic blocker in treating autonomic dysreflexia and hypertension but like mos...
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60-40-2 Mecamylamine

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60-40-2 METHYL-(2,3,3-TRIMETHYLTRINORBORNAN-2-YL)AMINE

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References of N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine
Title: Mecamylamine
CAS Registry Number: 60-40-2
CAS Name: N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine
Synonyms: N,2,3,3-tetramethyl-2-norbornanamine; N,2,3,3-tetramethyl-2-norcamphanamine; 3-methylaminoisocamphane; 2-methylaminoisocamphane; 2-methylamino-2,3,3-trimethylnorbornane; N-methyl-2-isocamphanamine; 3b-methylamino-2,2,3-trimethylbicyclo[2.2.1]heptane; mecamine
Molecular Formula: C11H21N
Molecular Weight: 167.29
Percent Composition: C 78.98%, H 12.65%, N 8.37%
Literature References: Nicotinic receptor antagonist; orally active ganglionic blocker. Prepn: G. A. Stein et al., J. Am. Chem. Soc. 78, 1514 (1956); K. Pfister, III, G. A. Stein, US 2831027 (1958 to Merck & Co.). Structure activity study: C. A. Stone et al., J. Med. Pharm. Chem. 5, 665 (1962). GC-MS determn in plasma: P. Jacob, III et al., J. Pharm. Biomed. Anal. 23, 653 (2000). Receptor binding study of isomers: R. L. Papke et al., J. Pharmacol. Exp. Ther. 297, 646 (2001). Review of pharmacology and clinical experience: J. M. Young et al., Clin. Ther. 23, 532-565 (2001).
Properties: Oily liquid. bp4.0 72°. nD25 1.4881. Slightly sol in water.
Boiling point: bp4.0 72°
Index of refraction: nD25 1.4881
 
Derivative Type: Hydrochloride
CAS Registry Number: 826-39-1
Trademarks: Inversine (Targacept)
Molecular Formula: C11H21N.HCl
Molecular Weight: 203.75
Percent Composition: C 64.84%, H 10.88%, N 6.87%, Cl 17.40%
Properties: Crystals, dec 245.5-246.5°. Bittersweet. Soly (g/100 ml): water 21.2; ethanol 8.2; glycerol 10.4; isopropanol 2.1. pH of 1% aq soln 6.0-7.5.
 
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive.