CAS No 59859-58-4 , Piperidine,3-[(4-methoxyphenoxy)methyl]-1-methyl-4-phenyl-, (3R,4S)-

Name: Piperidine,3-[(4-methoxyphenoxy)methyl]-1-methyl-4-phenyl-, (3R,4S)-
Synonyms: Piperidine,3-[(4-methoxyphenoxy)methyl]-1-methyl-4-phenyl-, (3R,4S)-;Piperidine,3-[(4-methoxyphenoxy)methyl]-1-methyl-4-phenyl-, (3R-trans)-; (+)-Femoxetine; Femoxetine;
CAS Registry Number:59859-58-4
Flash Point: 142.6°C
Boiling Point: 437.9°C at 760 mmHg
Density: 1.055g/cm³
Refractive index: 1.545
Flash Point: 142.6°C
Molecular Weight: 0
InChI: InChI=1/C20H25NO2/c1-21-13-12-20(16-6-4-3-5-7-16)17(14-21)15-23-19-10-8-18(22-2)9-11-19/h3-11,17,20H,12-15H2,1-2H3/t17-,20-/m1/s1
Molecular Formula: C20H25 N O2
Molecular Structure:

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References of Piperidine,3-[(4-methoxyphenoxy)methyl]-1-methyl-4-phenyl-, (3R,4S)-

Title: Femoxetine
CAS Registry Number: 59859-58-4
CAS Name: (3R,4S)-3-[(4-Methoxyphenoxy)methyl]-1-methyl-4-phenylpiperidine
Synonyms: (+)-trans-1-methyl-3-[p-(methoxy)phenoxymethyl]-4-phenylpiperidine
Molecular Formula: C20H25NO2
Molecular Weight: 311.42
Percent Composition: C 77.14%, H 8.09%, N 4.50%, O 10.28%
Literature References: Serotonin uptake inhibitor. Prepn: J. A. Christensen, R. F. Squires, BE 810310; eidem, US 3912743 (1974, 1975 both to A/S Ferrosan). Neuropharmacology: J. B. Lassen et al., Psychopharmacologia 42, 21 (1975). Pharmacology and toxicity: eidem, Eur. J. Pharmacol. 32, 108 (1975). GC determn in body fluids: E. Bechgaard, J. Lund, J. Chromatogr. 133, 147 (1977). Metabolism: H. Larsson, J. Lund, Acta Pharmacol. Toxicol. 48, 424 (1981). Bioavailability and pharmacokinetics: H. Mengel et al., Arzneim.-Forsch. 33, 462 (1983). Double-blind clinical trials in treatment of migraine: P. G. Andersson, E. N. Petersen, Acta Neurol. Scand. 64, 280 (1981); in treatment of endogenous depression: L.-E. Dahl et al., Acta Psychiatr. Scand. 66, 9 (1982); P. N. Reebye et al., Pharmacopsychiatria 15, 164 (1982).

Derivative Type: Hydrochloride
CAS Registry Number: 56222-04-9
Manufacturers' Codes: FG-4963
Trademarks: Malexil (Ferrosan)
Molecular Formula: C20H25NO2.HCl
Molecular Weight: 347.88
Percent Composition: C 69.05%, H 7.53%, N 4.03%, O 9.20%, Cl 10.19%
Properties: LD50 in female, male mice (mg/kg): 48, 45 i.v.; 941, 723 s.c.; 1408, 1687 orally (Lassen).
Toxicity data: LD50 in female, male mice (mg/kg): 48, 45 i.v.; 941, 723 s.c.; 1408, 1687 orally (Lassen)

Therap-Cat: Antidepressant.
Keywords: Antidepressant; Serotonin Uptake Inhibitor.