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CAS No 59803-98-4 , 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

  • Name: 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
  • Synonyms: brimonidinum; brimonidina;5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine; AGN 190342; 59803-98-4;Bromoxidine; UK 14,304; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 207.5 ºC
  • Flash Point: 215.4 ºC
  • Boiling Point: 432.6 ºC
  • Density: 1.82 g/cm3
  • Refractive index: 1.798
  • Safety Statements: R25;R36/37/38
  • Hazard Symbols: T: Toxic;
  • Flash Point: 215.4 ºC
  • Molecular Weight: 292.1346
  • InchiKey: XYLJNLCSTIOKRM-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/
    h1-4H,5-6H2,(H2,15,16,17)
  • Risk Statements: S26;S36;S45
  • Molecular Formula: C11H10BrN5
  • Molecular Structure:CAS No:59803-98-4 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine

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59803-98-4 BRIMONIDINE TARTRATE INTERMEDIATE 2: 5-BROMO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-QUINOXALINAMINE

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59803-98-4 BRIMONIDINE BASE

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59803-98-4 BRIMONIDE TARTRATE

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59803-98-4 brimonidine

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59803-98-4 5-BROMO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-QUINOXALINAMINE

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59803-98-4 Brimonidine

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59803-98-4 BRIMONIDINE

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References of 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)quinoxalin-6-amine
Title: Brimonidine
CAS Registry Number: 59803-98-4
CAS Name: 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine
Synonyms: 5-bromo-6-(2-imidazolin-2-ylamino)quinoxaline
Manufacturers' Codes: UK-14304; AGN-190342
Molecular Formula: C11H10BrN5
Molecular Weight: 292.13
Percent Composition: C 45.23%, H 3.45%, Br 27.35%, N 23.97%
Literature References: a2-Adrenoceptor agonist. Prepn: J. C. Danielewicz et al., DE 2309160; eidem, US 3890319 (1973, 1975 both to Pfizer). HPLC determn in serum and aqueous humour of the eye: N. K. Karamanos et al., Biomed. Chromatogr. 13, 86 (1999). Clinical study in control of intraocular pressure: R. David et al., Arch. Ophthalmol. 111, 1387 (1993); L. J. Katz et al., Am. J. Ophthalmol. 127, 20 (1999). Review of pharmacology and mechanisms of action: J. C. Adkins, J. A. Balfour, Drugs Aging 12, 225-241 (1998); of pharmacotherapeutic profile: L. B. Cantor, Expert Opin. Pharmacother. 1, 815-834 (2000).
Properties: Yellow crystals from ethanol, mp 252°.
Melting point: mp 252°
 
Derivative Type: D-Tartrate
CAS Registry Number: 70359-46-5
Manufacturers' Codes: UK-14304-18; AGN-190342-LF
Trademarks: Alphagan (Allergan)
Molecular Formula: C11H10BrN5.C4H6O6
Molecular Weight: 442.22
Percent Composition: C 40.74%, H 3.65%, Br 18.07%, N 15.84%, O 21.71%
Properties: White crystals from acetone, mp 207.5°.
Melting point: mp 207.5°
 
Therap-Cat: Antiglaucoma.
Keywords: Antiglaucoma.