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CAS No 59227-89-3 , 1-dodecylazepan-2-one

  • Name: 1-dodecylazepan-2-one
  • Synonyms: Tranzone; 59227-89-3; N-Dodecylcaprolactam; 1-dodecylazepan-2-one;Azone;1-dodecylazepan-2-one; N-Lauryl caprolactam; 1-Dodecylazacycloheptan-2-one;
  • CAS Registry Number:
  • Melting Point: -7 deg C
  • Boiling Point: 350
  • Density: 0.906-0.926
  • Refractive index: 1.470-1.473
  • Water Solubility: Insoluble in water, and form emulsions with water, soluble in various organic solvents.
  • EINECS: 261-668-9
  • Molecular Weight: 281.4766
  • InchiKey: AXTGDCSMTYGJND-UHFFFAOYSA-N
  • InChI: InChI=1S/C18H35NO/c1-2-3-4-5-6-7-8-9-10-13-16-19-17-14-11-12-15-18(19)
    20/h2-17H2,1H3
  • Molecular Formula: C18H35NO
  • Molecular Structure:CAS No:59227-89-3 1-dodecylazepan-2-one

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59227-89-3 LAUROCAPRAM

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59227-89-3 1-DODECYLHEXAHYDRO-2H-AZEPIN-2-ONE

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References of 1-dodecylazepan-2-one
Title: Laurocapram
CAS Registry Number: 59227-89-3
CAS Name: 1-Dodecylhexahydro-2H-azepin-2-one
Synonyms: 1-dodecylazacycloheptan-2-one; N-dodecyl-e-caprolactam
Manufacturers' Codes: N-0252
Trademarks: Azone (Nelson)
Molecular Formula: C18H35NO
Molecular Weight: 281.48
Percent Composition: C 76.81%, H 12.53%, N 4.98%, O 5.68%
Literature References: Caprolactam derivative used to enhance percutaneous absorption of physiologically active agents. Also exhibits intrinsic anti-inflammatory activity. Prepn: A. P. Swain et al., J. Org. Chem. 18, 1087 (1953). Improved synthesis: V. J. Rajadhyaksha et al., EP 95096; eidem, US 4422970 (both 1983 to Nelson). Use as skin penetrant: V. J. Rajadhyaksha, US 3989816; US 4405616 (1976, 1983 to Nelson). Anti-inflammatory activity: E. L. Nelson, US 4310525 (1982 to Nelson). Pharmacology: R. B. Stoughton, Arch. Dermatol. 118, 474 (1982). Comprehensive description: idem, Drug Dev. Ind. Pharm. 9, 725 (1983). Topical antiviral activity in vivo: M. F. Leonard et al., Chemotherapy (Basel) 33, 151 (1987).
Properties: Clear, colorless liquid, mp -7°. bp50m 160°. d 0.91; n 1.4701. Insol in water. Freely sol in most organic solvents. LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton).
Melting point: mp -7°
Boiling point: bp50m 160°
Index of refraction: n 1.4701
Density: d 0.91
Toxicity data: LD50 rats, mice (g/kg): 8 i.v., i.p. (Stoughton)
Use: Pharmaceutic aid (excipient).