Title: Prosultiamine
CAS Registry Number: 59-58-5
CAS Name: N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-
N-[4-hydroxy-1-methyl-2-(propyldithio)-1-butenyl]formamide
Synonyms: 2-(2-methyl-4-aminopyrimidin-5-yl)methylformamido-5-hydroxy-2-penten-3-yl propyl disulfide; vitamin B1 propyl disulfide; thiamine propyl disulfide; dithiopropylthiamine; DTPT; TPD
Trademarks: Alinamin (Takeda); Binova (Gentili)
Molecular Formula: C15H24N4O2S2
Molecular Weight: 356.51
Percent Composition: C 50.53%, H 6.79%, N 15.72%, O 8.98%, S 17.99%
Literature References: Synthesis: Matsukawa, Kawasuki,
J. Pharm. Soc. Jpn. 73, 216 (1953),
C.A. 48, 2071 (1954); Matsukawa
et al., J. Vitaminol. 1, 13 (1954); Fujiwara
et al., US 2833768 (1958 to Takeda),
cf. FR 1068459 (1954 to Takeda). Structural studies: Nishikawa
et al., Chem. Pharm. Bull. 17, 932 (1969). Metabolism: Suzuoki-Ziro
et al., J. Biochem. 58, 279 (1965); Nishikawa
et al., J. Pharmacol. Exp. Ther. 157, 589 (1967).
Properties: Prisms from benzene, dec 128-129°. Sparingly soluble in water. Sol in organic solvents and lipids. Better absorbed upon oral ingestion by man, than thiamine hydrochloride.
Derivative Type: Hydrochloride
CAS Registry Number: 973-99-9
Molecular Formula: C15H24N4O2S2.HCl
Molecular Weight: 392.97
Percent Composition: C 45.85%, H 6.41%, N 14.26%, O 8.14%, S 16.32%, Cl 9.02%
Properties: Crystals, dec 160-161°.
Therap-Cat: Vitamin (enzyme co-factor).
Keywords: Enzyme Cofactor; Vitamin/Vitamin Source; Vitamin B1.
