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CAS No 59-26-7 , N,N-diethylpyridine-3-carboxamide

  • Name: N,N-diethylpyridine-3-carboxamide
  • Synonyms: Nicethamide; Corvin; Nikethyl; Canfodiamina; Coramine; Nicotinic acid diethylamide;N,N-diethylpyridine-3-carboxamide;N,N-DIETHYLNICOTINAMIDE; Coraetamidum;
  • CAS Registry Number:
  • Transport: UN 2811 6.1/PG 3
  • Melting Point: 23 °C(lit.)
  • Flash Point: 141.1°C
  • Boiling Point: 296-300 °C(lit.)
  • Density: 1.06 g/mL at 25 °C(lit.)
  • Refractive index: 20/D 1.524(lit.)
  • Water Solubility: >=10 g/100 mL at 23 C
  • Safety Statements: R23/24/25:Toxicbyinhalation,incontactwithskinandifswallowed.;
  • Hazard Symbols: T:Toxic;
  • Flash Point: 141.1°C
  • EINECS: 200-418-5
  • Molecular Weight: 178.23096
  • InchiKey: NCYVXEGFNDZQCU-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
  • Risk Statements: S23:Donotinhalegas/fumes/vapour/spray.;S24:Avoidcontactwithskin.;
  • Molecular Formula: C10H14N2O
  • Molecular Structure:CAS No:59-26-7 N,N-diethylpyridine-3-carboxamide

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References of N,N-diethylpyridine-3-carboxamide
Title: Nikethamide
CAS Registry Number: 59-26-7
CAS Name: N,N-Diethyl-3-pyridinecarboxamide
Synonyms: N,N-diethylnicotinamide; pyridine-3-carboxylic acid diethylamide; nicotinic acid diethylamide
Trademarks: Anacardone; Astrocar; Carbamidal; Cardamine; Cardiamid; Cardimon; Coracon; Coractiv N (Phyteia); Coramine (Novartis); Cordiamin; Corediol (Meiji); Cormed (Reiss); Cormid; Corvitol; Corvotone; Dynacoryl; Eucoran; Inicardio; Niamine; Nicamide; Nicor; Nicorine; Nikardin; Pyricardyl; Salvacard; Stimulin; Ventramine
Molecular Formula: C10H14N2O
Molecular Weight: 178.23
Percent Composition: C 67.39%, H 7.92%, N 15.72%, O 8.98%
Literature References: Prepd by the action of thionyl chloride on nicotinic acid, followed by treatment with diethylamine hydrochloride; also formed by heating nicotinic acid or quinolinic acid anhydride with diethylamine: Hartmann, Seiberth, US 1403117 (1922); from nicotinic acid + benzenesulfonyldiethyl amide: Oxley et al., J. Chem. Soc. 1946, 763. Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).
Properties: Slightly viscous liquid or cryst solid. Faintly bitter taste followed by a faint sensation of warmth. d425 1.058-1.066 (liq). mp 24-26°. bp760 296-300° (some decompn); bp10 158-159°; bp3 128-129°; bp0.4 115°. nD20 1.525-1.526; nD25 1.522-1.524. Misc with water, ether, chloroform, acetone, alc. Usually marketed as a 25% w/v aq soln, pH 6.0-6.5. Incompatible with Na2CO3 solns which cause precipitation; tannates produce an amorph ppt. LD50 i.p. in rats: 272 mg/kg (Goldenthal).
Melting point: mp 24-26°
Boiling point: bp760 296-300° (some decompn); bp10 158-159°; bp3 128-129°; bp0.4 115°
Index of refraction: nD20 1.525-1.526; nD25 1.522-1.524
Density: d425 1.058-1.066 (liq)
Toxicity data: LD50 i.p. in rats: 272 mg/kg (Goldenthal)
Therap-Cat: CNS and respiratory stimulant.
Therap-Cat-Vet: Respiratory stimulant.
Keywords: CNS Stimulant; Respiratory Stimulant.