Home > Name List By u > Ubenimex China

CAS No 58970-76-6 , Ubenimex Search by region : China

  • Name: Ubenimex
  • Synonyms: [S-(R*,S*)]-N-(3-Amino-2-hydroxy-1-oxo-4-phenylbuty1)-L-leucine;bestatin;Ubenimex;Bestatin;
  • CAS Registry Number:
  • Melting Point: 245 ºC
  • Density: 1.197 g/cm3/sup>
  • Refractive index: 1.557
  • Safety Statements: 22-24/25
  • EINECS: 261-529-2
  • Molecular Weight: 308.38
  • InChI: InChI=1/C16H24N2O4/c1-10(2)8-13(16(21)22)18-15(20)14(19)12(17)9-11-6-4-3-5-7-11/h3-7,10,12-14,19H,8-9,17H2,1-2H3,(H,18,20)(H,21,22)/t12-,13+,14+/m1/s1
  • Risk Statements: S24/25
  • Molecular Formula: C16H24N2O4
  • Molecular Structure:CAS No:58970-76-6 Ubenimex

Related products

Select to

58970-76-6 Bestatin

  • China Chemrio International Limited [Manufacturer]
  • Tel: +86 574 2789 1268/ +86-139 5789 5864 (mobile)
  • Fax: +86 574 2789 1266
  • Address: Chemrio International Limited
    Room 611-612, Wante Business Center
    No.487 Yangmuqi Road,
    Hi-tech Park Ningbo, 315040,China null,nullChina
Contact Supplier

58970-76-6 ubenimex

Contact Supplier

58970-76-6 Ubenimex

  • UbenimexUbenimex, 98%
  • China PMIDA AGROCHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-023-67030808-8010
  • Fax: +86-023-67030809
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone401121 ChongqingCHINA Chongqing,nullChina
Contact Supplier

58970-76-6 Ubenimex

  • Ubenimex, 98%
  • China Shanghai Rainbow Chemistry Co., Ltd. [Manufacturer]
  • Tel: +86-21-64968086
  • Fax: +86-21-64968086
  • Address: Room 128, Building B, No. 8 Lane 1305, Huajing Road, Xuhui District, Shanghai, P.R. China 200000 Shanghai CHINA Shanghai,nullChina
Contact Supplier

58970-76-6 Ubenimex

  • Ubenimex
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
Contact Supplier

58970-76-6 Ubenimex

  • Ubenimex
  • China Shenzhen sailing chemical Co.,Ltd [Manufacturer]
  • Tel: 86-755-26415005
  • Fax: 86-755-26412646
  • Address: 1-403 Bei tou hao yuan Nanxing Road Nanshan District Shenzhen, Guangdong 518051 shenzhenCHINA shenzhen,nullChina
Contact Supplier

58970-76-6 Bestatin

  • Bestatin, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

58970-76-6 Bestatin

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
  • Fax: +86-(21)-38218795
  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
Contact Supplier

58970-76-6 ubenimex

  • China Boronsyn Co.,Ltd [Manufacturer]
  • Tel: +86-21-58407925
  • Fax: +86-21-58408291
  • Address: 1213 JunMin Road,Pudong,China null,nullChina
Contact Supplier

58970-76-6 Ubenimex

Contact Supplier

Select to

References of Ubenimex
Title: Ubenimex
CAS Registry Number: 58970-76-6
CAS Name: N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine
Manufacturers' Codes: NK-421
Trademarks: Bestatin (Nippon Kayaku)
Molecular Formula: C16H24N2O4
Molecular Weight: 308.37
Percent Composition: C 62.32%, H 7.84%, N 9.08%, O 20.75%
Literature References: Dipeptide antitumor antibiotic produced by Streptomyces olivoreticuli with immunostimulant activity; inhibits leucine aminopeptidase and aminopeptidases B and N. Prepn from fermentation broth: H. Umezawa et al., DE 2528984; eidem, US 4052449 (1976, 1977 both to Microbiochem. Res. Found., Japan); eidem, J. Antibiot. 29, 97 (1976). Structure: H. Suda et al., ibid. 100. Synthesis of stereoisomers and structure-activity study: R. Nishizawa et al., J. Med. Chem. 20, 510 (1977). Stereocontrolled synthesis: S. Kobayashi et al., Tetrahedron Lett. 25, 5079 (1984). Crystal structure: J. S. Ricci, Jr. et al., J. Org. Chem. 47, 3063 (1982). Cell surface binding studies: H. Umezawa et al., J. Antibiot. 29, 857 (1976); W. E. Müller et al., Int. J. Immunopharmacol. 4, 393 (1982). Acute toxicity: T. Sakakibara et al., Jpn. J. Antibiot. 36, 2971 (1983). Review of pharmacology: G. Mathé, Biomed. Pharmacother. 45, 49-54 (1991); of clinical studies: K. Ota, ibid. 55-60. Clinical trial in squamous-cell lung carcinoma: Y. Ichinose et al., J. Natl. Cancer Inst. 95, 605 (2003).
Properties: Colorless needles, mp 233-236°. [a]D20 -15.5° (c = 1.0 in 1N HCl). pKa 8.1, 3.1. uv max: 241.5, 248, 253, 258, 264.5, 268 nm (E1%1cm 3.8, 4.0, 5.0, 6.0, 4.6, 2.7). Sol in acetic acid, DMSO, methanol. Less sol in water. Insol in ethyl acetate, benzene, hexane, chloroform. LD50 in male, female mice, male, female rats (g/kg): 1.3, 1.9, 1.9, 2.1 s.c.; 0.19, 0.19, 0.90, 0.78 i.p.; >4.0, >4.0, >2.0, >2.0 orally (Sakakibara).
Melting point: mp 233-236°
pKa: pKa 8.1, 3.1
Optical Rotation: [a]D20 -15.5° (c = 1.0 in 1N HCl)
Absorption maximum: uv max: 241.5, 248, 253, 258, 264.5, 268 nm (E1%1cm 3.8, 4.0, 5.0, 6.0, 4.6, 2.7)
Toxicity data: LD50 in male, female mice, male, female rats (g/kg): 1.3, 1.9, 1.9, 2.1 s.c.; 0.19, 0.19, 0.90, 0.78 i.p.; >4.0, >4.0, >2.0, >2.0 orally (Sakakibara)
Therap-Cat: Immunomodulator; antineoplastic.
Keywords: Antineoplastic; Immunomodulators; Immunomodulator.