Home > Name List By other > (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3, 4-dihydroxyoxolan-2-yl]hexanoic acid

CAS No 58944-73-3 , (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,
4-dihydroxyoxolan-2-yl]hexanoic acid

  • Name: (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,
    4-dihydroxyoxolan-2-yl]hexanoic acid
  • Synonyms: ADENOSYL-ORNITHINE;(2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,
    4-dihydroxyoxolan-2-yl]hexanoic acid; Adenosylornithine; Sinefungine; Sinefunginum; Antibiotic 32232 RP;Compound 57926; Sinefungina; Antibiotic A 9145;
  • CAS Registry Number:
  • Melting Point: 381.387
  • Flash Point: 427.5°C
  • Boiling Point: 783.2°C at 760 mmHg
  • Density: 1.91g/cm3
  • Refractive index: 1.831
  • Safety Statements: 36
  • Hazard Symbols: Xn
  • Flash Point: 427.5°C
  • Molecular Weight: 381.38702
  • InchiKey: LMXOHSDXUQEUSF-YECHIGJVSA-N
  • InChI: InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-
    5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,
    26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
  • Risk Statements: 22
  • Molecular Formula: C15H23N7O5
  • Molecular Structure:CAS No:58944-73-3 (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,<br />4-dihydroxyoxolan-2-yl]hexanoic acid
Search by region :

Select to

58944-73-3 SINEFUNGIN

  • United States 2A PharmaChem USA [Manufacturer]
  • Tel: 630-322-8887
  • Fax: 630-322-8885
  • Address: 2A PharmaChem USA
    5403 Patton Drive, Suite 208
    Lisle, Illinois 60532 null,nullUnited States
Contact Supplier

58944-73-3 SINEFUNGIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
Contact Supplier

Select to

References of (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,
4-dihydroxyoxolan-2-yl]hexanoic acid
Title: Sinefungin
CAS Registry Number: 58944-73-3
CAS Name: 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-a-L-talo-decofuranuronic acid
Synonyms: Compd 57926; Antibiotic 32232RP
Manufacturers' Codes: A-9145
Molecular Formula: C15H23N7O5
Molecular Weight: 381.39
Percent Composition: C 47.24%, H 6.08%, N 25.71%, O 20.98%
Literature References: Adenine-containing antibiotic produced by Streptomyces griseoleus NRRL 3739. Isoln: R. L. Hamill, M. M. Hoehn, US 3758681 (1973 to Lilly); eidem, J. Antibiot. 26, 463 (1973). Antifungal activity: R. S. Gordee, T. F. Butler, ibid. 466. Antiprotozoal activity: D. K. Dube et al., Am. J. Trop. Med. Hyg. 32, 31 (1983); A. Ferrante et al., Trans. R. Soc. Trop. Med. Hyg. 78, 837 (1984); P. Paolantonacci et al., Antimicrob. Agents Chemother. 28, 528 (1985); E. Zweygarth et al., Trop. Med. Parasitol. 37, 255 (1986); in vivo antileishmanial activity: J. L. Avila et al., Am. J. Trop. Med. Hyg. 43, 139 (1990). Synthesis: M. Geze et al., J. Am. Chem. Soc. 105, 7638 (1983); stereoselective synthesis: M. P. Maguire et al., J. Org. Chem. 55, 948 (1990). Inhibition of methyltransferase: R. T. Borchardt et al., Biochem. Biophys. Res. Commun. 89, 919 (1979).
Properties: White powder. Sol in water, very slightly sol in methanol and ethanol. Insol in organic solvents. Stable at room temp in aq soln from pH 1 to 11. pKa (66% DMF): 2.9, 3.9, 8.9, 10.2. uv max in neutral solns: 206 nm, 258 nm (E1cm1% 520, 325); in basic solns: 256 nm (E1cm1% 325). [a]D25 -2.61° (c = 5 in water). Also reported as [a]D23 +12 ±2° (c = 0.227 in water). LD50 s.c. in mice: 185 mg/kg (Hamill, Hoehn, J. Antibiot.)
pKa: pKa (66% DMF): 2.9, 3.9, 8.9, 10.2
Optical Rotation: [a]D25 -2.61° (c = 5 in water); [a]D23 +12 ±2° (c = 0.227 in water)
Absorption maximum: uv max in neutral solns: 206 nm, 258 nm (E1cm1% 520, 325)
Toxicity data: LD50 s.c. in mice: 185 mg/kg (Hamill, Hoehn, J. Antibiot.)