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CAS No 58694-52-3 , tertiapin

  • Name: tertiapin
  • CAS Registry Number:
  • Molecular Weight: 2459.13
  • InChI: InChI=1S/C106H180N34O23S5/c1-11-56(7)83(137-93(151)68(32-24-39-118-106(115)116)126-97(155)73(45-80(112)141)130-101(159)78(53-167)136-98(156)74(46-81(113)142)131-100(158)77(52-166)135-94(152)70(42-55(5)6)128-87(145)58(9)111)103(161)138-84(57(8)12-2)104(162)139-85(59(13-3)14-4)105(163)140-40-25-33-79(140)102(160)132-72(44-61-48-117-54-121-61)96(154)127-69(34-41-168-10)92(150)134-76(51-165)99(157)129-71(43-60-47-119-63-27-16-15-26-62(60)63)95(153)125-66(29-18-21-36-108)90(148)124-67(30-19-22-37-109)91(149)133-75(50-164)88(146)120-49-82(143)122-65(31-23-38-110)89(147)123-64(86(114)144)28-17-20-35-107/h15-16,26-27,47-48,54-59,64-79,83-85,119,164-167H,11-14,17-25,28-46,49-53,107-111H2,1-10H3,(H2,112,141)(H2,113,142)(H2,114,144)(H,117,121)(H,120,146)(H,122,143)(H,123,147)(H,124,148)(H,125,153)(H,126,155)(H,127,154)(H,128,145)(H,129,157)(H,130,159)(H,131,158)(H,132,160)(H,133,149)(H,134,150)(H,135,152)(H,136,156)(H,137,151)(H,138,161)(H,139,162)(H4,115,116,118)/t56-,57-,58-,64?,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76?,77-,78-,79-,83-,84-,85-/m0/s1
  • Molecular Formula: C106H180N34O23S5
  • Molecular Structure:CAS No:58694-52-3 tertiapin
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58694-52-3 N-1745.0500 H-ALA-LEU-CYS-ASN-CYS-ASN-ARG-ILE-ILE-ILE-PRO-HIS-MET-CYS-TRP-LYS-LYS-CYS-GLY-LYS-LYS-NH2, (DISULFIDE BONDS BETWEEN CYS3 AND CYS14/CYS5 AND CYS18)

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58694-52-3 H-ALA-LEU-CYS-ASN-CYS-ASN-ARG-ILE-ILE-ILE-PRO-HIS-MET-CYS-TRP-LYS-LYS-CYS-GLY-LYS-LYS-NH2, (DISULFIDE BONDS BETWEEN CYS3 AND CYS14/CYS5 AND CYS18) TERTIAPIN

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References of tertiapin
Title: Tertiapin
CAS Registry Number: 58694-52-3
Synonyms: TPN
Literature References: Neurotoxic 21 residue peptide isolated from the venom of the European honey bee, Apis mellifera. Characterized by 2 disulfide linkages and the complete absence of negatively charged residues, it selectively inhibits G-protein inwardly rectifying potassium channels (GIRK) by binding to the external vestibule of the channel. Isoln: J. Gauldie et al., Eur. J. Biochem. 61, 369 (1976); B. E. C. Banks et al., Bull. Instit. Pasteur 74, 137 (1976). Primary structure: Y. A. Ovchinnikov et al., Soviet J. Bioorg. Chem. 6, 187 (1980); 3D-structure: X. Xu, J. W. Nelson, Proteins Struct. Funct. Genet. 17, 124 (1993). Inhibition of GIRK-channels: W. Jin, Z. Lu, Biochemistry 37, 13291 (1998); of muscarinic inwardly rectifying potassium channels (IK(ACh)): M.-D. Drici et al., Br. J. Pharmacol. 131, 569 (2000); D. E. Benavides-Haro et al., Arch. Pharm. 368, 309 (2003).
 
Derivative Type: Tertiapin Q
CAS Registry Number: 252198-49-5
Synonyms: TPNQ
Literature References: Non-air-oxidizable derivative of TPN in which Met-13 is replaced with Gln. Synthesis: W. Jin, Z. Lu, Biochemistry 38, 14286 (1999). Mechanism of inhibition: W. Jin et al., ibid. 14294. Proton titration of TPNQ binding: Y. Ramu et al., ibid. 40, 3601 (2001).
 
Use: Biochemical probe for potassium channels.