CAS No 58186-27-9 , 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione Search by region : Germany

Name: 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
Synonyms: 58186-27-9;2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione; Idebenone [INN:JAN]; Idebenona [Spanish]; Idebenonum [Latin];
CAS Registry Number:58186-27-9
Melting Point: 52-550ºC
Flash Point: 170.1 ºC
Boiling Point: 497.3 ºC at 760 mmHg
Density: 1.08 g/cm³
Refractive index: 1.502
Hazard Symbols: Xi: Irritant;
Flash Point: 170.1 ºC
Molecular Weight: 338.4385
InchiKey: JGPMMRGNQUBGND-UHFFFAOYSA-N
InChI: InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18
(23-2)16(14)21/h20H,4-13H2,1-3H3
Risk Statements: Xi
Molecular Formula: C₁₉H₃₀O₅
Molecular Structure:

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References of 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Title: Idebenone
CAS Registry Number: 58186-27-9
CAS Name: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Synonyms: 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone; 2,3-dimethoxy-5-methyl-6-(10￠-hydroxydecyl)-1,4-benzoquinone; 6-(10-hydroxydecyl)ubiquinone
Manufacturers' Codes: CV-2619
Trademarks: Avan (Takeda); Daruma (Takeda); Lucebanol (Hormona); Mnesis (Takeda)
Molecular Formula: C19H30O5
Molecular Weight: 338.44
Percent Composition: C 67.43%, H 8.93%, O 23.64%
Literature References: Ubiquinone derivative with protective effects against cerebral ischemia. Prepn: H. Morimoto et al., DE 2519730; eidem, US 4271083 (1975, 1981 both to Takeda); K. Okamoto et al., Chem. Pharm. Bull. 30, 2797 (1982); C.-A. Yu, L. Yu, Biochemistry 21, 4096 (1982). Effect on ischemia-induced amnesia in rats: N. Yamazaki et al., Jpn. J. Pharmacol. 36, 349 (1984). Metabolism in animals: T. Kobayashi et al., J. Pharmacobio-Dyn. 8, 448 (1985). Disposition: H. Torii et al., ibid. 457. Pharmacokinetics and tolerance in humans: M. F. Barkworth et al., Arzneim.-Forsch. 35, 1704 (1985). Series of articles on pharmacology and clinical studies: Arch. Gerontol. Geriatr. 8, 193-366 (1989). Review of chemistry, toxicology and pharmacology: I. Zs-Nagy, Arch. Gerontol. Geriatr. 11, 177-186 (1990).
Properties: Orange needles from ligroin, mp 46-50° (Morimoto); also reported as crystals from hexane + ethyl acetate, mp 52-53° (Okamoto). Sol in organic solvents. Practically insol in water.
Melting point: mp 46-50° (Morimoto); mp 52-53° (Okamoto)
Therap-Cat: Nootropic.
Keywords: Nootropic.