Title: Deslorelin
CAS Registry Number: 57773-65-6
CAS Name: 6-D-Tryptophan-9-(
N-ethyl-L-prolinamide)-10-deglycinamideluteinizing hormone-releasing factor (pig)
Synonyms: [D-Trp6,des-Gly10]-LH-RH ethylamide
Trademarks: Somagard (Roberts)
Molecular Formula: C64H83N17O12
Molecular Weight: 1282.45
Percent Composition: C 59.94%, H 6.52%, N 18.57%, O 14.97%
Literature References: Synthetic nonapeptide agonist analog of LH-RH,
q.v. Prepn: D. H. Coy
et al., J. Med. Chem. 19, 423 (1976); W. Kornreich
et al., Int. J. Pept. Protein Res. 25, 414 (1985). Pharmacology: K. Sundaram
et al., Life Sci. 28, 83 (1981). Pharmacokinetics and metabolism: B. Candas
et al., J. Clin. Endocrinol. Metab. 70, 1046 (1990). Clinical inhibition of spermatogenesis: R. Linde
et al., N. Engl. J. Med. 305, 663 (1981). Clinical trial in combination with flutamide,
q.v., for prostatic carcinoma: A. Dupont
et al., Eur. J. Cancer Clin. Oncol. 24, 659 (1988). Clinical evaluation in precocious puberty: P. K. Manasco
et al., J. Pediatr. 115, 105 (1989).
Properties: [a]D24 -61° (c = 0.37 in 0.1
M acetic acid).
Optical Rotation: [a]D24 -61° (c = 0.37 in 0.1
M acetic acid)
Therap-Cat: Treatment of precocious puberty.
Keywords: LH-RH Agonist.
