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CAS No 57773-65-6 , Deslorelin

  • Name: Deslorelin
  • Synonyms: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt;Deslorelin; Deslorelin Acetate;Deslorelin acetate; [d- trp6 ,des-gly10 ]-lh-rh ethylamide; Deslorelin;(Des-Gly10,D-Trp6,Pro-NHEt9)-LHRH;
  • CAS Registry Number:
  • Density: 1.48 g/cm3
  • Safety Statements: 53-22-36/37/39-45
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 1282.46
  • InChI: InChI=1/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45?,46-,47?,48-,49+,50-,51-,52-,53-/m0/s1
  • Risk Statements: 60
  • Molecular Formula: C64H83N17O12
  • Molecular Structure:CAS No:57773-65-6 Deslorelin

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57773-65-6 [d- trp6,des-gly10]-lh-rh ethylamide

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57773-65-6 [D- TRP6 ,DES-GLY10 ]-LH-RH ETHYLAMIDE

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References of Deslorelin
Title: Deslorelin
CAS Registry Number: 57773-65-6
CAS Name: 6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing hormone-releasing factor (pig)
Synonyms: [D-Trp6,des-Gly10]-LH-RH ethylamide
Trademarks: Somagard (Roberts)
Molecular Formula: C64H83N17O12
Molecular Weight: 1282.45
Percent Composition: C 59.94%, H 6.52%, N 18.57%, O 14.97%
Literature References: Synthetic nonapeptide agonist analog of LH-RH, q.v. Prepn: D. H. Coy et al., J. Med. Chem. 19, 423 (1976); W. Kornreich et al., Int. J. Pept. Protein Res. 25, 414 (1985). Pharmacology: K. Sundaram et al., Life Sci. 28, 83 (1981). Pharmacokinetics and metabolism: B. Candas et al., J. Clin. Endocrinol. Metab. 70, 1046 (1990). Clinical inhibition of spermatogenesis: R. Linde et al., N. Engl. J. Med. 305, 663 (1981). Clinical trial in combination with flutamide, q.v., for prostatic carcinoma: A. Dupont et al., Eur. J. Cancer Clin. Oncol. 24, 659 (1988). Clinical evaluation in precocious puberty: P. K. Manasco et al., J. Pediatr. 115, 105 (1989).
Properties: [a]D24 -61° (c = 0.37 in 0.1M acetic acid).
Optical Rotation: [a]D24 -61° (c = 0.37 in 0.1M acetic acid)
Therap-Cat: Treatment of precocious puberty.
Keywords: LH-RH Agonist.