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CAS No 57695-04-2 , N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine

  • Name: N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine
  • Synonyms: WR6026; WR 6026; 57695-04-2; CHEMBL57004;Sitamaquine; UNII-5AIJ4TGC6B; NSC2452; SureCN1070741;N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine; 5330-29-0; WR-6026;
  • CAS Registry Number:
  • Flash Point: 257.9°C
  • Boiling Point: 502.8°C at 760 mmHg
  • Density: 1.033g/cm3
  • Refractive index: 1.567
  • Flash Point: 257.9°C
  • Molecular Weight: 343.50622
  • InchiKey: RVAKDGYPIVSYEU-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H33N3O/c1-5-24(6-2)14-10-8-7-9-12-22-20-16-18(25-4)15-19-17
    (3)11-13-23-21(19)20/h11,13,15-16,22H,5-10,12,14H2,1-4H3
  • Molecular Formula: C21H33N3O
  • Molecular Structure:CAS No:57695-04-2 N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine

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57695-04-2 1,6-Hexanediamine,N1,N1-diethyl-N6-(6-methoxy-4-methyl-8-quinolinyl)-

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57695-04-2 SITAMAQUINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of N',N'-diethyl-N-(6-methoxy-4-methylquinolin-8-yl)hexane-1,6-diamine
Title: Sitamaquine
CAS Registry Number: 57695-04-2
CAS Name: N,N-Diethyl-N￠-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine
Synonyms: 8-(6￠-diethylaminohexylamino)-6-methoxylepidine; 6-methoxy-8-(6-diethylaminohexylamine)-4-methylquinoline; kalazaquine
Manufacturers' Codes: WR-6026
Molecular Formula: C21H33N3O
Molecular Weight: 343.51
Percent Composition: C 73.43%, H 9.68%, N 12.23%, O 4.66%
Literature References: 8-Aminoquinolone; analog of the antimalarial agent primaquine, q.v. Prepn: K. N. Campbell et al., J. Am. Chem. Soc. 68, 1556 (1946); idem, US 2508937 (1950 to USA, as represented by the Secy. of War). Antileishmanial activity in hamsters: K. E. Kinnamon et al., Am. J. Trop. Med. Hyg. 27, 751 (1978). HPLC determn in plasma: J. C. Anders et al., J. Chromatogr. 311, 117 (1984). Clinical evaluation in AIDS-associated Pneumocystis carinii pneumonia: B. G. Petty et al., J. Acquir. Immune Defic. Syndr. 21, 26 (1999); in visceral leishmaniasis: R. Dietze et al., Am. J. Trop. Med. Hyg. 65, 685 (2001). Ex vivo use in prevention of transfusion-associated Chagas' disease: H. Moraes-Souza et al., Rev. Soc. Bras. Med. Trop. 35, 563 (2002). Review of clinical development: C. Yeates, Curr. Opin. Invest. Drugs 3, 1446-1452 (2002); H. Sangraula et al., J. Assoc. Physicians India 51, 686-690 (2003).
Properties: bp0.05 190-200°.
Boiling point: bp0.05 190-200°
 
Derivative Type: Dihydrochloride
CAS Registry Number: 5330-29-0
Molecular Formula: C21H33N3O.2HCl
Molecular Weight: 416.43
Percent Composition: C 60.57%, H 8.47%, N 10.09%, O 3.84%, Cl 17.03%
Properties: Yellow crystals from propanol, mp 179-180°.
Melting point: mp 179-180°
 
Therap-Cat: Antiprotozoal (Leishmania).
Keywords: Antiprotozoal (Leishmania).