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CAS No 57149-07-2 , 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol Search by region : China

  • Name: 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
  • Synonyms: NCGC00015718-06;Flivas; BRN 0629965; Naftopidilum [Latin]; KT-611; 57149-07-2; Avishot; Naftopidil (unspecified);1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;
  • CAS Registry Number:
  • Melting Point: 127 °C
  • Boiling Point:
  • Density: 1.184 g/cm3
  • Water Solubility: methanol: >10 mg/mL
  • Hazard Symbols: UN NO.
  • Molecular Weight: 392.49072
  • InchiKey: HRRBJVNMSRJFHQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H28N2O3/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20
    (27)18-29-23-12-6-8-19-7-2-3-9-21(19)23/h2-12,20,27H,13-18H2,1H3
  • Molecular Formula: C24H28N2O3
  • Molecular Structure:CAS No:57149-07-2 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol

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References of 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol
Title: Naftopidil
CAS Registry Number: 57149-07-2
CAS Name: 4-(2-Methoxyphenyl)-a-[(1-naphthalenyloxy)methyl]-1-piperazineethanol
Synonyms: RS-1-[4-(2-methoxyphenyl)-1-piperazinyl]-3-(1-naphthoxy)-2-propanol; 1-(2-methoxyphenyl)-4-[3-(naphth-1-yloxy)-2-hydroxypropyl]-piperazine
Manufacturers' Codes: KT-611
Trademarks: Avishot (Kanebo); Flivas (Asahi)
Molecular Formula: C24H28N2O3
Molecular Weight: 392.49
Percent Composition: C 73.44%, H 7.19%, N 7.14%, O 12.23%
Literature References: a1-Adrenergic blocker and serotonin (5HT1A) receptor agonist. Prepn: E. C. Witte et al., DE 2408804; eidem, US 3997666 (1975, 1976 both to Boehringer Mann.). Clinical pharmacodynamics: R. Kirsten et al., Eur. J. Clin. Pharmacol. 46, 271 (1994). Clinical pharmacokinetics: M. J. G. Farthing et al., Postgrad. Med. J. 70, 363 (1994). HPLC determn in human plasma: G. Niebch et al., J. Chromatogr. 534, 247 (1990). Clinical evaluation in BPH: K. Yasuda et al., Prostate 25, 46 (1994). Review of pharmacology and clinical experience: H. M. Himmel, Cardiovasc. Drug Rev. 12, 32-47 (1994).
Properties: Crystals from isopropanol, mp 125-126°; also reported as colorless crystals, mp 125-129°. Insol in water. Partition coefficient (octanol/water): 75. LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel).
Melting point: mp 125-126°; mp 125-129°
Log P: Partition coefficient (octanol/water): 75
Toxicity data: LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel)
 
Derivative Type: Dihydrochloride
CAS Registry Number: 57149-08-3
Molecular Formula: C24H28N2O3.2HCl
Molecular Weight: 465.41
Percent Composition: C 61.94%, H 6.50%, N 6.02%, O 10.31%, Cl 15.24%
Properties: Crystals from methanol/ethanol (1:2), mp 212-213°.
Melting point: mp 212-213°
 
Therap-Cat: Antihypertensive; a-blocker in treatment of symptomatic benign prostate hypertrophy.
Keywords: a-Adrenergic Blocker; Antihypertensive.