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CAS No 57021-61-1 , 3-Pyridinecarboxamide,N-(2,6-dimethylphenyl)-1,2-dihydro-2-oxo-

  • Name: 3-Pyridinecarboxamide,N-(2,6-dimethylphenyl)-1,2-dihydro-2-oxo-
  • Synonyms: Isonixine;Isonixin;3-Pyridinecarboxamide,N-(2,6-dimethylphenyl)-1,2-dihydro-2-oxo-; Nixyn;
  • CAS Registry Number:
  • Flash Point: 217.5°C
  • Boiling Point: 520.5°C at 760 mmHg
  • Density: 1.244g/cm3
  • Refractive index: 1.628
  • Safety Statements: Mildly toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 217.5°C
  • EINECS: 260-521-6
  • Molecular Weight: 228.29
  • InChI: InChI=1/C14H14N2O2/c1-9-5-3-6-10(2)12(9)16-14(18)11-7-4-8-15-13(11)17/h3-8H,1-2H3,(H,15,17)(H,16,18)
  • Molecular Formula: C14H14 N2 O2
  • Molecular Structure:CAS No:57021-61-1 3-Pyridinecarboxamide,N-(2,6-dimethylphenyl)-1,2-dihydro-2-oxo-

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References of 3-Pyridinecarboxamide,N-(2,6-dimethylphenyl)-1,2-dihydro-2-oxo-
Title: Isonixin
CAS Registry Number: 57021-61-1
CAS Name: N-(2,6-Dimethylphenyl)-1,2-dihydro-2-oxo-3-pyridinecarboxamide
Synonyms: 2-pyridone-3-carboxylic acid 2,6-xylidide; 2-hydroxy-2￠,6￠-nicotinoxylidide
Trademarks: Nixyn (Organon)
Molecular Formula: C14H14N2O2
Molecular Weight: 242.27
Percent Composition: C 69.41%, H 5.82%, N 11.56%, O 13.21%
Literature References: Non-steroidal anti-inflammatory agent. Prepn: J.-A. Canicio Chimeno, BE 820578; idem, US 4031105 (1975, 1977 both to Hermes). Prepn, pharmacology and toxicity: R. Cadena et al., Arzneim.-Forsch. 27, 1457 (1977). Toxicological study: M. T. Mitjavila et al., ibid. 1460. Absorption, excretion studies: G. Carrera et al., ibid. 29, 1401 (1979). Tolerance in humans: T. M. Serra et al., Therapie 35, 173 (1980). HPLC determn in plasma: F. González Lopez et al., Farmaco Ed. Prat. 38, 273 (1983).
Properties: White crystalline powder from ethanol, mp 266-267°. Sol in chloroform and strong alkali. Practically insol in acids and water. LD50 in male, female mice, male, female rats (mg/kg): 7000, 8000, >6000, >6000 orally; all >2000 i.p. (Cadena).
Melting point: mp 266-267°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 7000, 8000, >6000, >6000 orally; all >2000 i.p. (Cadena)
Therap-Cat: Analgesic, anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Aminoarylcarboxylic Acid Derivatives.