Title: Picloxydine
CAS Registry Number: 5636-92-0
CAS Name: N,N¢¢-Bis[[(4-chlorophenyl)amino]iminomethyl]-1,4-piperazine dicarboximidamide
Synonyms: N,N¢¢-bis[(
p-chlorophenyl)amidino]-1,4-piperazinedicarboxamidine; 1,4-bis(
N4¢-
p-chlorophenylamidinoamidinyl)piperazine; 1,1¢-[1,4-piperazinediylbis(imidocarbonyl)]bis[3-(
p-chlorophenyl)guanidine]
Molecular Formula: C20H24Cl2N10
Molecular Weight: 475.38
Percent Composition: C 50.53%, H 5.09%, Cl 14.92%, N 29.46%
Literature References: Heterocyclic biguanide with antibacterial activity. Prepn: J. W. James, L. F. Wiggins,
GB 855017;
eidem, US 3101336 (1960, 1963 both to Aspro-Nicholas). Prepn and antibacterial spectrum: J. W. James
et al., J. Med. Chem. 11, 942 (1968). Bactericidal effect in disinfectant formulations: A. M. Gordon,
J. Clin. Pathol. 22, 496 (1969). Mode of action study: B. D. Rawal, J. V. Hardy,
Microbios 14, 135 (1974).
In vitro activity vs
Chlamydia trachomatis: D. Thomas
et al., Pathol. Biol. 32, 544 (1984).
Derivative Type: Dihydrochloride
CAS Registry Number: 19803-62-4
Trademarks: Vitabact (Faure)
Molecular Formula: C20H24Cl2N10.2HCl
Molecular Weight: 548.30
Percent Composition: C 43.81%, H 4.78%, Cl 25.86%, N 25.55%
Properties: Crystals from water, mp 274°. LD50 in mice (mg/kg): 150 i.p. (James).
Melting point: mp 274°
Toxicity data: LD50 in mice (mg/kg): 150 i.p. (James)
Therap-Cat: Antibacterial (topical).
Keywords: Antiseptic/Disinfectant; Guanidines.