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CAS No 56124-62-0 , Valrubicin

  • Name: Valrubicin
  • Synonyms: [2-Oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate;Valrubicin;
  • CAS Registry Number:
  • Melting Point: 116-117 ºC
  • Boiling Point: 135-136 C
  • Density: 1.54 g/cm3
  • Refractive index: 1.618
  • Safety Statements: Poison by intraperitoneal route. Human mutation data reported. When heated to decomposition it emits toxic fumes of F− and NOx.
  • Hazard Symbols: Xi
  • Molecular Weight: 723.64
  • InChI: InChI=1/C34H36F3NO13/c1-4-5-9-21(40)49-13-20(39)33(47)11-16-24(19(12-33)51-22-10-17(27(41)14(2)50-22)38-32(46)34(35,36)37)31(45)26-25(29(16)43)28(42)15-7-6-8-18(48-3)23(15)30(26)44/h6-8,14,17,19,22,27,41,43,45,47H,4-5,9-13H2,1-3H3,(H,38,46)/t14?,17?,19-,22?,27?,33-/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C34H36F3NO13
  • Molecular Structure:CAS No:56124-62-0 Valrubicin

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56124-62-0 VALRUBICIN

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56124-62-0 Valrubicin

  • China Zhejiang Holypharm Biotech Co., Ltd. [Manufacturers]
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References of Valrubicin
Title: Valrubicin
CAS Registry Number: 56124-62-0
CAS Name: Pentanoic acid 2-[(2S,4S)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-[[2,3,6-trideoxy-3-[(trifluoroacetyl)amino]-a-L-lyxo-hexopyranosyl]oxy]-2-naphthacenyl]-2-oxoethyl ester
Synonyms: N-trifluoroacetyladriamycin-14-valerate
Manufacturers' Codes: AD-32; NSC-246131
Trademarks: Valstar (Medeva)
Molecular Formula: C34H36F3NO13
Molecular Weight: 723.64
Percent Composition: C 56.43%, H 5.01%, F 7.88%, N 1.94%, O 28.74%
Literature References: Semisynthetic doxorubicin, q.v., analog. Prepn: M. Israel et al., Cancer Res. 35, 1365 (1975); M. Israel, E. J. Modest, US 4035566 (1977 to S. Farber Cancer Inst.). TLC determn in biological samples: B. Barbieri et al., J. Chromatogr. 163, 195 (1979). Clinical pharmacokinetics: R. E. Greenberg et al., Urology 49, 471 (1997). Clinical trial in refractory bladder cancer: G. Steinberg et al., J. Urol. 163, 761 (2000). Review of pharmacology and clinical development: C. Doehn, Curr. Opin. Oncol. Endocr. Metab. Invest. Drugs 1, 407-415 (1999); S. V. Onrust, H. M. Lamb, Drugs Aging 15, 69-75 (1999).
Properties: Orange or orange-red powder, mp 135-136°. Highly lipophilic. Sol in methylene chloride, ethanol, methanol, acetone. Practically insol in water.
Melting point: mp 135-136°
Therap-Cat: Antineoplastic
Keywords: Antineoplastic; Antibiotics and Analogs; Anthracyclines.