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CAS No 55453-87-7 , 2-(11-oxo-6H-benzo[c][1]benzoxepin-2-yl)acetic acid

  • Name: 2-(11-oxo-6H-benzo[c][1]benzoxepin-2-yl)acetic acid
  • Synonyms: HP 549; 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid;2-(11-oxo-6H-benzo[c][1]benzoxepin-2-yl)acetic acid; nd4-b2; Artil; P 720549; Isoxepacum [INN-Latin];Arelix; 55453-87-7;
  • CAS Registry Number:
  • Density: 1.349 g/cm3
  • Refractive index: 1.635
  • Molecular Weight: 268.26408
  • InchiKey: QFGMXJOBTNZHEL-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H12O4/c17-15(18)8-10-5-6-14-13(7-10)16(19)12-4-2-1-3-11(12)
    9-20-14/h1-7H,8-9H2,(H,17,18)
  • Molecular Formula: C16H12O4
  • Molecular Structure:CAS No:55453-87-7 2-(11-oxo-6H-benzo[c][1]benzoxepin-2-yl)acetic acid

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References of 2-(11-oxo-6H-benzo[c][1]benzoxepin-2-yl)acetic acid
Title: Isoxepac
CAS Registry Number: 55453-87-7
CAS Name: 6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid
Synonyms: oxepinac
Manufacturers' Codes: HP-549; P-720549
Trademarks: Artil (Hoechst)
Molecular Formula: C16H12O4
Molecular Weight: 268.26
Percent Composition: C 71.64%, H 4.51%, O 23.86%
Literature References: Non-steroidal anti-inflammatory with analgesic and antipyretic activity. Prepn: K. Ueno et al., JP Kokai 74 124086 (1974 to Daiichi), C.A. 82, 170735d (1975); G. C. Helsley et al., DE 2442060; eidem, US 4585788 (1975, 1986 both to Hoechst); K. Ueno et al., J. Med. Chem. 19, 941 (1976); D. E. Aultz et al., ibid. 20, 66 (1977). Pharmacology: H. B. Lassman et al., Arch. Int. Pharmacodyn. Ther. 227, 142 (1977). Disposition and metabolism in animals and humans: H. P. A. Illing, J. M. Fromson, Drug Metab. Dispos. 6, 510 (1978). HPLC determn in plasma: J. A. Slack, J. Chromatogr. 221, 431 (1980); H. K. L. Hundt, L. W. Brown, ibid. 225, 482 (1981). Clinical studies: S. Sasaki, Arzneim.-Forsch. 28, 462 (1978); L. B. Svendsen et al., Scand. J. Rheumatol. 10, 186 (1981); J. Scott, E. C. Huskisson, Rheumatol. Rehabil. 21, 48 (1982).
Properties: Crystals from ethyl acetate, mp 131-132.5°. LD50 orally in rats: 199 mg/kg (Ueno).
Melting point: mp 131-132.5°
Toxicity data: LD50 orally in rats: 199 mg/kg (Ueno)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.