References of Arsonic acid,As-[4-[(2-amino-2-oxoethyl)amino]phenyl]-, sodium salt (1:1)
Title: Tryparsamide
CAS Registry Number: 554-72-3
CAS Name: [4-[(2-Amino-2-oxoethyl)amino]phenyl]arsonic acid monosodium salt
Synonyms: N-(carbamoylmethyl)arsanilic acid monosodium salt; monosodium
N-phenylglycinamide-
p-arsonate
Trademarks: Glyphenarsine; Tryparsone; Tryponarsyl; Trypothane
Molecular Formula: C8H10AsN2NaO4
Molecular Weight: 296.09
Percent Composition: C 32.45%, H 3.40%, As 25.30%, N 9.46%, Na 7.76%, O 21.61%
Literature References: Prepd by heating a soln of arsanilic acid in aq NaOH, Na2CO3 and chloroacetamide: Jacobs, Heidelberger,
J. Am. Chem. Soc. 41, 1590 (1919);
Org. Synth. 8, 100 (1928).
US 1280119;
US 1280124;
US 1280126 (1918);
US 2465308 (1949).
Derivative Type: Hemihydrate
Properties: Platelets, slowly affected by light, stable to air. One gram dissolves in about 2 ml water. Slightly sol in alcohol. Insol in ether, chloroform. pH of 1:20 aq soln 6.5.
Keep tryparsamide in tight containers, preferably at a temp not above 20° and protected from light.
Therap-Cat: Antiprotozoal (Trypanosoma).
Keywords: Antiprotozoal (Trypanosoma).