CAS No 554-18-7 , D-Glucitol,1,1'-[sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-, sodium salt (1:2)

Name: D-Glucitol,1,1'-[sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-, sodium salt (1:2)
Synonyms: Protomin;D-Glucitol,1,1'-[sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-, sodium salt (1:2); Glucosulfone, disodium salt (8CI); Angeli's sulfone; Promin;Angeli sulfone;Solfone; Sulfona P; S.N. 166;D-Glucitol,1,1'-[sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-, disodium salt(9CI); Aceprosol; Promin sodium;NSC 512486; NSC 36701; Promanide; 501 Siegfried; Tasmin; Glucosulfone sodium; Glucosulfone; 501P; Sodium glucosulfone;
CAS Registry Number:554-18-7
Flash Point: °C
Boiling Point: °Cat760mmHg
Density: g/cm³
Safety Statements: Poison by ingestion, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of SO_x, NO_x, and Na₂O.
Flash Point: °C
EINECS: 209-064-6
Molecular Weight: 780.76
InChI: InChI=1/C24H36N2O18S3.2Na/c27-9-15(29)17(31)19(33)21(35)23(46(39,40)41)25-11-1-5-13(6-2-11)45(37,38)14-7-3-12(4-8-14)26-24(47(42,43)44)22(36)20(34)18(32)16(30)10-28;;/h1-8,15-36H,9-10H2,(H,39,40,41)(H,42,43,44);;/q;2*+1/p-2/t15-,16-,17-,18-,19+,20+,21-,22-,23?,24?;;/m1../s1
Molecular Formula: C24H36 N2 O18 S3 . 2 Na
Molecular Structure:

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References of D-Glucitol,1,1'-[sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-, sodium salt (1:2)

Title: Glucosulfone Sodium
CAS Registry Number: 554-18-7
CAS Name: 1,1￠-[Sulfonylbis(4,1-phenyleneimino)]bis[1-deoxy-1-sulfo-D-glucitol] disodium salt
Synonyms: p,p￠-sulfonyldianiline N,N￠-diglucoside disodium disulfonate; p,p￠-sulfonyldianiline-N,N￠-di-D-glucose sodium bisulfite compd; p,p￠-diaminodiphenylsulfone-N,N￠-di(dextrose sodium sulfonate); disodium p,p￠-diaminodiphenylsulfone-N,N￠-diglucose sulfonate
Manufacturers' Codes: 501-P
Trademarks: Protomin; Promin (Parke-Davis); Promanide
Molecular Formula: C24H34N2Na2O18S3
Molecular Weight: 780.70
Percent Composition: C 36.92%, H 4.39%, N 3.59%, Na 5.89%, O 36.89%, S 12.32%
Literature References: Prepd by refluxing a mixture of 4,4￠-diaminodiphenylsulfone, glucose, sodium bisulfite, and 80% ethanol: CH 234108 (1944 to B. Siegfried), C.A. 43, 4297a (1949); B. C. Jain et al., Sci. Cult. 11, 568 (1946). Structure activity study: W. Logemann, G. P. Miori, Arzneim.-Forsch. 5, 213 (1955). Clinical evaluation in ocular leprosy: A. Bouzas, Arch. Ophthalmol. 31, 629 (1971).
Properties: White, amorphous powder. Soluble in water; slightly sol in ethanol. Insol in ether, benzene, methanol, ethyl acetate, pyridine. Aq solns may be sterilized by autoclaving. LD50 in rats (g/kg): 3-4 orally, 3-3.5 i.v. (Logemann, Miori).
Toxicity data: LD50 in rats (g/kg): 3-4 orally, 3-3.5 i.v. (Logemann, Miori)
Therap-Cat: Antibacterial (leprostatic).
Keywords: Antibacterial (Synthetic); Sulfones; Antibacterial (Leprostatic).