Title: N-Nitrosodiethylamine
CAS Registry Number: 55-18-5
CAS Name: N-Ethyl-
N-nitrosoethanamine
Synonyms: diethylnitrosamine
Trademarks: DEN; DENA; NDEA
Molecular Formula: C4H10N2O
Molecular Weight: 102.14
Percent Composition: C 47.04%, H 9.87%, N 27.43%, O 15.66%
Line Formula: (C2H5)2NNO
Literature References: Detected in trace amounts in tobacco smoke: Druckney, Preussman,
Naturwissenschaften 49, 498 (1962) and in various processed foods: Hedler, Marquardt,
Food Cosmet. Toxicol. 6, 341 (1968); Friemuth, Glaeser,
Nahrung 14, 357 (1970). Formed by the interaction of nitrite with diethylamine and by the action of nitrate-reducing bacteria. Industrial prepn: Reilly,
DE 1085166 (1960 to du Pont),
C.A. 56, 4594h (1962); Levering, Maury,
US 3090786 (1963 to Hercules Powder); Minisci, Galli,
Chim. Ind. (Milan) 46, 173 (1964). Hepatotoxicity and carcinogenicity studies: Schmaehl
et al., Naturwissenschaften 54, 341 (1967); Grover, Fischer,
Eur. J. Cancer 7, 77 (1971); Bader
et al., Arch. Geschwulstforsch. 37, 327 (1971). General review: Magee, Barnes,
Adv. Cancer Res. 10, 163-246 (1967).
Properties: Slightly yellow liq. d420 0.9422. bp 175-177°. bp5 47°.
nD20 1.4388. Sol in water, alc, ether.
Boiling point: bp 175-177°; bp5 47°
Index of refraction: nD20 1.4388
Density: d420 0.9422
CAUTION: This substance is reasonably anticipated to be a human carcinogen:
Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-198.
Use: Gasoline and lubricant additive; antioxidant; stabilizer in plastics.