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CAS No 54749-90-5 , D-Glucose,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-

  • Name: D-Glucose,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
  • Synonyms: CHLZ; NCI 178248; NSC 178248;Chlorozotocin; Chlorozotocine; DCNU;D-Glucose,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-;
  • CAS Registry Number:
  • Transport: 3249
  • Melting Point: 147-148 deg C (decomposes with evolution of gas)
  • Density: 1.858g/cm3
  • Refractive index: 1.664
  • Safety Statements: Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also NITROSAMINES.
  • Molecular Weight: 313.73
  • InChI: InChI=1/C9H16ClN3O7/c10-1-2-13(12-19)9(18)11-5-7(16)6(15)4(3-14)20-8(5)17/h4-8,14-17H,1-3H2,(H,11,18)/t4-,5-,6-,7-,8?/m1/s1
  • Molecular Formula: C9H16 Cl N3 O7
  • Molecular Structure:CAS No:54749-90-5 D-Glucose,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-

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References of D-Glucose,2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-
Title: Chlorozotocin
CAS Registry Number: 54749-90-5
CAS Name: 2-[[[(2-Chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-D-glucose
Synonyms: 2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose; 1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea; DCNU
Manufacturers' Codes: NSC-178248
Molecular Formula: C9H16ClN3O7
Molecular Weight: 313.69
Percent Composition: C 34.46%, H 5.14%, Cl 11.30%, N 13.40%, O 35.70%
Literature References: Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, lomustine, nimustine, ranimustine, q.q.v; 2-chloroethyl analog of streptozotocin, q.v. Synthesis: H. D. Burns et al., Org. Prep. Proced. Int. 6, 259 (1974); T. P. Johnston et al., J. Med. Chem. 18, 104 (1975). Pharmacology: T. Anderson et al., Cancer Res. 35, 761 (1975); P. S. Schein et al., Cancer Treat. Rep. 60, 801 (1976). Decomposition in aqueous media: J. A. Montgomery et al., J. Med. Chem. 18, 568 (1975).
Properties: Ivory colored crystals, mp 147-148° (dec with the evolution of gas), (Burns, Heindel). Also reported as mp 140-141° (dec), (Johnston). Sol in water.
Melting point: mp 147-148° (dec with the evolution of gas); mp 140-141° (dec)
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-62.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Nitrosoureas.