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CAS No 546-06-5 , Conessine Search by region : Germany

  • Name: Conessine
  • Synonyms: 3-beta-(dimethylamino)-con-5-enin;n-dimethyl-(3-beta)-con-5-enin-3-amin;WRIGHTINE;NERIINE;ROGUESSINE;N,N-Dimethyl-con-5-enin-3-amine;n,18-dihydrotrimethyl-conkurchin;NERVINE;CONESSINE(P);NeriineRoquessineWrightine;Conessine;Neriine;CONESSINE(RG);3-beta-(dimethylamino)con-5-enine;
  • CAS Registry Number:
  • Melting Point: 126-127°C
  • Flash Point: 199.6°C
  • Boiling Point: 450.4°C at 760 mmHg
  • Density: 1.05g/cm3
  • Refractive index: 1.564
  • Flash Point: 199.6°C
  • EINECS: 208-897-2
  • Molecular Weight: 356.59
  • InChI: InChI=1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
  • Molecular Formula: C24H40N2
  • Molecular Structure:CAS No:546-06-5 Conessine

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546-06-5 Conessine

  • Conessine
  • Germany ABCR GmbH & Co KG [Manufacturer]
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546-06-5 Conessine

  • Conessine
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References of Conessine
Title: Conessine
CAS Registry Number: 546-06-5
CAS Name: (3b)-N,N-Dimethylcon-5-enin-3-amine
Synonyms: 3b-(dimethylamino)con-5-enine; neriine; roquessine; wrightine
Molecular Formula: C24H40N2
Molecular Weight: 356.59
Percent Composition: C 80.84%, H 11.31%, N 7.86%
Literature References: Antiamebic, antifungal principle in Kurchi bark, the bark of Holarrhena anti-dysenterica Wall., Apocynaceae, native to India; also found in African species, such as H. africana A.DC.; H. congolensis Stapf; H. wulfsbergii Stapf, and H. febrifuga Klotzsch, Apocynaceae. Isoln: Haines, Trans. Med. Soc. Bombay 4, 28 (1858); Warnecke, Ber. 19, 60 (1886); Bertho, Arch. Pharm. 277, 237 (1939); Siddiqui, Pillay, J. Indian Chem. Soc. 9, 553 (1932). Structure: Haworth et al., J. Chem. Soc. 1953, 1102; Haworth, McKenna, Chem. Ind. (London) 1957, 1510; Bertho, G?tz, Ann. 619, 96 (1958). Discussion of structure in Fieser, Fieser, Steroids (New York, 1959), p 858. Synthesis from D5-pregnene-3b,20b-diol: Barton, Morgan, Proc. Chem. Soc. London 1961, 206; J. Chem. Soc. 1962, 622. Total synthesis: Marshall, Johnson, J. Am. Chem. Soc. 84, 1485 (1962); Stork et al., ibid. 2018; Nagata et al., Tetrahedron Lett. 1963, 869.
Properties: Leaflets or broad plates from acetone, mp 127-128.5°. [a]D20 +25.3° (c = 0.7 in abs alc). Sparingly sol in water.
Melting point: mp 127-128.5°
Optical Rotation: [a]D20 +25.3° (c = 0.7 in abs alc)
 
Derivative Type: Dihydrochloride monohydrate
Molecular Formula: C24H40N2.2HCl.H2O
Molecular Weight: 447.52
Percent Composition: C 64.41%, H 9.91%, N 6.26%, Cl 15.84%, O 3.58%
Properties: Crystals, sol in water, mp >340°. [a]D20 +9.3° (c = 0.9 in H2O).
Melting point: mp >340°
Optical Rotation: [a]D20 +9.3° (c = 0.9 in H2O)
 
Derivative Type: Dihydrobromide
CAS Registry Number: 5913-82-6
Molecular Formula: C24H40N2.2HBr
Molecular Weight: 518.41
Percent Composition: C 55.60%, H 8.17%, N 5.40%, Br 30.83%
Properties: Crystals, dec 340°. Very bitter taste. [a]D20 +7.0° (c = 5 in H2O). Sol in water. Slightly sol in 95% ethanol. Very slightly sol in ether. Practically insol in petr ether.
Optical Rotation: [a]D20 +7.0° (c = 5 in H2O)