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CAS No 54340-62-4 , Bufuralol

  • Name: Bufuralol
  • Synonyms: Bufuralol;
  • CAS Registry Number:
  • Flash Point: 191.6°C
  • Boiling Point: 393.2°C at 760 mmHg
  • Density: 1.066g/cm3
  • Refractive index: 1.558
  • Safety Statements: Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. When heated to decomposition it emits very toxic fumes of Cl− and NOx. See also AMINES.
  • Flash Point: 191.6°C
  • EINECS: 259-112-5
  • Molecular Weight: 261.3593
  • InChI: InChI=1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3
  • Molecular Formula: C16H23NO2•ClH
  • Molecular Structure:CAS No:54340-62-4 Bufuralol
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54340-62-4 Bufuralol

  • Bufuralol, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
Contact Supplier

54340-62-4 BUFURALOL-D9

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. null,nullIndia
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54340-62-4 BUFURALOL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Bufuralol
Title: Bufuralol
CAS Registry Number: 54340-62-4
CAS Name: a-[[(1,1-Dimethylethyl)amino]methyl]-7-ethyl-2-benzofuranmethanol
Synonyms: a-[(tert-butylamino)methyl]-7-ethyl-2-benzofuranmethanol; 2-(2-tert-butylamino-1-hydroxyethyl)-7-ethylbenzofuran; 1-(7-ethylbenzofuran-2-yl)-2-tert-butylamino-1-hydroxyethane
Molecular Formula: C16H23NO2
Molecular Weight: 261.36
Percent Composition: C 73.53%, H 8.87%, N 5.36%, O 12.24%
Literature References: b-Adrenergic blocker with peripheral vasodilating activity. Prepn: NL 6606441; G. A. Fothergill et al., US 3929836 (1966, 1975 both to Hoffmann-La Roche). Prepn and resolution of isomers: eidem, Experientia 31, 1322 (1975); eidem, Arzneim.-Forsch. 27, 981 (1977). Pharmacology: T. C. Hamilton, M. W. Parkes, ibid. 1410. HPLC determn in plasma: P. Haefelfinger, J. Chromatogr. 221, 327 (1980). Metabolism of isomers and racemate: R. J. Francis et al., Eur. J. Clin. Pharmacol. 23, 529 (1982). Pharmacokinetics in hypertensive patients: M. Eckert et al., ibid. 24, 479 (1983). Hemodynamic effects in patients with angina: M. Pfisterer et al., J. Cardiovasc. Pharmacol. 6, 417 (1984).
 
Derivative Type: Hydrochloride
CAS Registry Number: 59652-29-8
Manufacturers' Codes: Ro-3-4787
Trademarks: Angium (Roche)
Molecular Formula: C16H23NO2.HCl
Molecular Weight: 297.82
Percent Composition: C 64.53%, H 8.12%, N 4.70%, O 10.74%, Cl 11.90%
Properties: Fine, white powder from acetone, mp 146°. LD50 in mice (mg/kg): 29.7 i.v.; 88.0 i.p.; 177 orally; in rats (mg/kg): 1400 s.c.; 750 orally (Hamilton, Parkes).
Melting point: mp 146°
Toxicity data: LD50 in mice (mg/kg): 29.7 i.v.; 88.0 i.p.; 177 orally; in rats (mg/kg): 1400 s.c.; 750 orally (Hamilton, Parkes)
 
Derivative Type: (+)-Hydrochloride
CAS Registry Number: 57704-11-7
Properties: Crystals from ethyl acetate-ether, mp 122-123°. [a]20365 +135.0° (c = 1.0 in ethanol).
Melting point: mp 122-123°
Optical Rotation: [a]20365 +135.0° (c = 1.0 in ethanol)
 
Derivative Type: (-)-Hydrochloride
CAS Registry Number: 57704-10-6
Properties: Crystals from ethyl acetate-ether, mp 122-123°. [a]20365 -136.0° (c = 1.0 in ethanol).
Melting point: mp 122-123°
Optical Rotation: [a]20365 -136.0° (c = 1.0 in ethanol)
 
Therap-Cat: Antianginal; antihypertensive.
Keywords: ?Adrenergic Blocker; Antianginal; Antihypertensive; Arylethanolamine Derivatives.