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CAS No 54063-53-5 , 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one

  • Name: 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
  • Synonyms: Propafenonum;Rythmol; Propafenone-HCl;1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one; Propafenonum [INN-Latin]; Propafenona [INN-Spanish]; Propafenone (INN); 54063-53-5; Propafenona;
  • CAS Registry Number:
  • Melting Point: 171 - 174 C
  • Boiling Point:
  • Density: 1.096 g/cm3
  • Refractive index: 1.557
  • Water Solubility: Slightly soluble
  • Safety Statements: 53-36/37/39-45
  • Hazard Symbols: UN NO.
  • EINECS: 258-955-6
  • Molecular Weight: 341.44398
  • InchiKey: JWHAUXFOSRPERK-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)
    13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3
  • Risk Statements: 46-22
  • Molecular Formula: C21H27NO3
  • Molecular Structure:CAS No:54063-53-5 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one

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References of 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one
Title: Propafenone
CAS Registry Number: 54063-53-5
CAS Name: 1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone
Synonyms: 2￠-[2-hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone
Manufacturers' Codes: SA-79
Molecular Formula: C21H27NO3
Molecular Weight: 341.44
Percent Composition: C 73.87%, H 7.97%, N 4.10%, O 14.06%
Literature References: Sodium channel blocker. Prepn: R. Sachse, DE 2001431 (1971 to Helopharm), C.A. 75, 151538f (1971). Pharmacology: H.-J. Hapke, E. Prigge, Arzneim.-Forsch. 26, 1849 (1976). Pharmacokinetics: M. Hollmann et al., ibid. 33, 763 (1983). HPLC determn in plasma and urine: U. Hofmann et al., J. Chromatogr. B 748, 113 (2000). Review of pharmacology and therapeutic efficacy: H. M. Bryson et al., Drugs 45, 85-130 (1993). Review of clinical trials in supraventricular arrhythmias and atrial fibrillation: A. P. Rae, Am. J. Cardiol. 82, 59N-65N (1998); S. C. Reimold et al., ibid. 66N-71N.
 
Derivative Type: Hydrochloride
CAS Registry Number: 34183-22-7
Trademarks: Arythmol (Abbott); Pronon (Yamanouchi); Rythmol (Abbott); Rytmonorm (Abbott)
Molecular Formula: C21H27NO3.HCl
Molecular Weight: 377.90
Percent Composition: C 66.74%, H 7.47%, N 3.71%, O 12.70%, Cl 9.38%
Properties: Fine white crystals. Slightly bitter taste. Sol in basic lower aliphatic alcohols, CCl4, hot water; slightly sol in cold water. Insol in ether. LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge).
Toxicity data: LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge)
 
Therap-Cat: Antiarrhythmic (class IC).
Keywords: Antiarrhythmic.