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CAS No 53902-12-8 , 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid Search by region : China

  • Name: 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid
  • Synonyms: 3,4-DAA; Tranilastum;Rizaben; SB-252218; S1439_Selleck; Tranilastum [INN-Latin]; 53902-12-8;2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid; Rizaben (TN);
  • CAS Registry Number:
  • Melting Point: 166-168 ºC
  • Flash Point: 585.6 °C at 760 mmHg
  • Boiling Point: 585.6 °C at 760 mmHg
  • Density: 1.299 g/cm3
  • Refractive index: 1.647
  • Water Solubility: Soluble to 100 mM in DMSO
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 585.6 °C at 760 mmHg
  • Molecular Weight: 327.33128
  • InchiKey: NZHGWWWHIYHZNX-CSKARUKUSA-N
  • InChI: InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-
    5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
  • Risk Statements: S26;S36
  • Molecular Formula: C18H17NO5
  • Molecular Structure:CAS No:53902-12-8 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid

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  • Product Name: Tranilast Certification:ISO9001 CAS: 53902-12-8 MF: C18H17NO5 MW: 327.33 Assay: 99% Standard: enterprise Standard Packaging : 25kg/drum or according to customer's requirement Payment Terms:L/C or T/T ,Bank Transfer and WU. Delivery Time...
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References of 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid
Title: Tranilast
CAS Registry Number: 53902-12-8
CAS Name: 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]benzoic acid
Synonyms: N-(3￠,4￠-dimethoxycinnamoyl)anthranilic acid
Manufacturers' Codes: N-5￠
Trademarks: Rizaben (Kissei)
Molecular Formula: C18H17NO5
Molecular Weight: 327.33
Percent Composition: C 66.05%, H 5.23%, N 4.28%, O 24.44%
Literature References: Orally active anti-allergic agent. Prepn: K. Harita et al., DE 2402398; idem, US 3940422 (1974, 1976 both to Kissei). Pharmacological properties: H. Azuma et al., Br. J. Pharmacol. 58, 483 (1976). Mechanism of action study: Y. Iijima et al., Biochem. Biophys. Res. Commun. 93, 912 (1980). Clinical study in pediatric bronchial asthma: H. Shioda, Allergy 34, 213 (1979). Toxicity studies: M. Nakazawa et al., Oyo Yakuri 12, 385, 407 (1976), C.A. 88, 115327-8 (1978). Series of articles on teratogenicity tests: Iyakuhin Kenkyu 9, 148-193 (1978), C.A. 88, 130930f, 146300m-303q (1978).
Properties: Crystals from chloroform, mp 211-213°. LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385).
Melting point: mp 211-213°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 780, 680, 1600, 1100 orally; 410, 385, 405, 395 i.p.; 2630, 2820, 3630, 3060 s.c. (Nakazawa, p 385)
Therap-Cat: Antiallergic.
Keywords: Antiallergic.