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CAS No 53808-88-1 , 2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetic acid

  • Name: 2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetic acid
  • Synonyms: Lonazolaco [INN-Spanish]; 53808-88-1; Irritren; Lonazolacum; Lonazolacum [INN-Latin];2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetic acid; Lonazolac [INN]; Lonazolac (INN);Lonazolaco;
  • CAS Registry Number:
  • Flash Point: 271.4°C
  • Boiling Point: 525.1°Cat760mmHg
  • Density: 1.3g/cm3
  • Flash Point: 271.4°C
  • EINECS: 258-791-5
  • Molecular Weight: 312.75032
  • InchiKey: XVUQHFRQHBLHQD-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H13ClN2O2/c18-14-8-6-12(7-9-14)17-13(10-16(21)22)11-20(19-
    17)15-4-2-1-3-5-15/h1-9,11H,10H2,(H,21,22)
  • Molecular Formula: C17H13ClN2O2
  • Molecular Structure:CAS No:53808-88-1 2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetic acid

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53808-88-1 1H-Pyrazole-4-acetic acid, 3-(4-chlorophenyl)-1-ph...

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53808-88-1 LONAZOLAC

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References of 2-[3-(4-chlorophenyl)-1-phenylpyrazol-4-yl]acetic acid
Title: Lonazolac
CAS Registry Number: 53808-88-1
CAS Name: 3-(4-Chlorophenyl)-1-phenyl-1H-pyrazole-4-acetic acid
Molecular Formula: C17H13ClN2O2
Molecular Weight: 312.75
Percent Composition: C 65.29%, H 4.19%, Cl 11.34%, N 8.96%, O 10.23%
Literature References: Prepn: R. A. Newberry, GB 1373212 (1974 to Wyeth), C.A. 82, 72987t (1975); G. Rainer, US 4146721 (1979 to Byk Gulden); G. Rainer et al., Arzneim.-Forsch. 31, 649 (1981). Pharmacology: R. Riedel, ibid. 655. Clinical studies: G. Lonauer et al., Z. Rheumatol. 40, 161 (1981); W. Siegmeth, P. Placheta, Wien. Klin. Wochenschr. 94, 145 (1982).
Properties: Crystals from ethanol/water, mp 150-151°. uv max (methanol): 281 nm (e 24800); (0.1N NaOH): 281 nm (e 23700). pKa 4.3. LD50 in male mice, rats (mg/kg): 195, 165 i.v. (Riedel).
Melting point: mp 150-151°
pKa: pKa 4.3
Absorption maximum: uv max (methanol): 281 nm (e 24800); (0.1N NaOH): 281 nm (e 23700)
Toxicity data: LD50 in male mice, rats (mg/kg): 195, 165 i.v. (Riedel)
 
Derivative Type: Calcium salt
CAS Registry Number: 75821-71-5
Trademarks: Argun L (Merckle); Irritren (Byk Gulden)
Molecular Formula: C34H24CaCl2N4O4
Molecular Weight: 663.56
Percent Composition: C 61.54%, H 3.65%, Ca 6.04%, Cl 10.69%, N 8.44%, O 9.64%
Properties: Solid, melts between 270-290° (dec). uv max (0.1N NaOH): 280 nm (e 46400). LD50 in male, female mice, male, female rats (mg/kg): 670, 845, 730, 1000 orally (Riedel).
Melting point: melts between 270-290° (dec)
Absorption maximum: uv max (0.1N NaOH): 280 nm (e 46400)
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 670, 845, 730, 1000 orally (Riedel)
 
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.