Title: Domiphen Bromide
CAS Registry Number: 538-71-6
CAS Name: N,N-Dimethyl-
N-(2-phenoxyethyl)-1-dodecanaminium bromide
Synonyms: dodecyldimethyl(2-phenoxyethyl)ammonium bromide; (b-phenoxyethyl)dimethyldodecylammonium bromide; PDDB; phenododecinium bromide
Manufacturers' Codes: NSC-39415
Trademarks: Bradosol (Novartis); Oradol (Novartis); Modicare; Neo-Bradoral (Novartis)
Molecular Formula: C22H40BrNO
Molecular Weight: 414.46
Percent Composition: C 63.75%, H 9.73%, Br 19.28%, N 3.38%, O 3.86%
Literature References: Prepd by heating phenoxyethyldimethylamine with dodecyl bromide: Hartmann, Bosshard,
US 2581336 (1952 to Ciba).
Properties: Crystals, mild characteristic odor, bitter taste, mp 112-113°. Freely sol in water (100 g/100 ml), much less sol at low temps. Sol in ethanol, acetone, ethyl acetate, chloroform; very slightly sol in benzene. Aq solns are clear, colorless, and foam profusely on shaking. pH of 10% soln: 6.42; of 1% commercial product at 25°: 5.5; of 0.1%: 6.8. Surface tension values at 25° (by the capillary rise method) range from 26.75 dynes/cm (10% soln) to 22.08 dynes/cm (0.1% soln). Incompatible with soap.
Melting point: mp 112-113°
Therap-Cat: Anti-infective (topical).
Keywords: Antiseptic/Disinfectant; Quaternary Ammonium Compounds.
