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CAS No 537-12-2 , 1,2-Propanediol,3-(1-piperidinyl)-, 1,2-bis(N-phenylcarbamate), hydrochloride (1:1)

  • Name: 1,2-Propanediol,3-(1-piperidinyl)-, 1,2-bis(N-phenylcarbamate), hydrochloride (1:1)
  • Synonyms: Diperodon hydrochloride;1,2-Propanediol,3-(1-piperidinyl)-, 1,2-bis(N-phenylcarbamate), hydrochloride (1:1);3-(1-Piperidinyl)-1,2-propanediyl bis(N-phenylcarbamate) hydrochloride; Diothanehydrochloride; NSC 76069;1,2-Propanediol, 3-piperidino-, dicarbanilate (ester), monohydrochloride (8CI);1,2-Propanediol,3-(1-piperidinyl)-, bis(phenylcarbamate) (ester), monohydrochloride (9CI); Proctodon;1,2-Propanediol, 3-piperidino-, dicarbanilate, hydrochloride (6CI,7CI);
  • CAS Registry Number:
  • Flash Point: 257.4°C
  • Boiling Point: 502°Cat760mmHg
  • Density: g/cm3
  • Safety Statements: Poison by subcutaneous and intravenous routes. When heated to decomposition it emits toxic fumes of NOx and HCl.
  • Hazard Symbols: Xi
  • Flash Point: 257.4°C
  • EINECS: 208-659-8
  • Molecular Weight: 433.98
  • InChI: InChI=1/C22H27N3O4.ClH/c26-21(23-18-10-4-1-5-11-18)28-17-20(16-25-14-8-3-9-15-25)29-22(27)24-19-12-6-2-7-13-19;/h1-2,4-7,10-13,20H,3,8-9,14-17H2,(H,23,26)(H,24,27);1H
  • Risk Statements: 36/37/38
  • Molecular Formula: C22H27 N3 O4 . Cl H
  • Molecular Structure:CAS No:537-12-2 1,2-Propanediol,3-(1-piperidinyl)-, 1,2-bis(N-phenylcarbamate), hydrochloride (1:1)

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537-12-2 Diperodon Hydrochloride

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537-12-2 DIPERODON HCL

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References of 1,2-Propanediol,3-(1-piperidinyl)-, 1,2-bis(N-phenylcarbamate), hydrochloride (1:1)
Title: Diperodon Hydrochloride
CAS Registry Number: 537-12-2
CAS Name: 3-(1-Piperidinyl)-1,2-propanediol bis(phenylcarbamate) (ester) monohydrochloride
Synonyms: 3-piperidino-1,2-propanediol dicarbanilate hydrochloride; 3-(1-piperidyl)-1,2-propanediol dicarbanilate hydrochloride; di(phenylurethan) of 1-piperidinepropane-2,3-diol hydrochloride
Trademarks: Diothane Hydrochloride (HMR); Proctodon (Rowell)
Molecular Formula: C22H28ClN3O4
Molecular Weight: 433.93
Percent Composition: C 60.89%, H 6.50%, Cl 8.17%, N 9.68%, O 14.75%
Literature References: Prepn: T. H. Rider, J. Am. Chem. Soc. 52, 2115 (1930); idem, US 2004132 (1935). Stability of solns: E. S. Cook, T. H. Rider, J. Am. Pharm. Assoc. 26, 222 (1937). Pharmacology: eidem, J. Pharmacol. 64, 1 (1938). X-ray crystallographic study: R. C. Sullivan, K. P. O'Brien, Bull. Narc. 20, 31 (1968). IR spectra: eidem, ibid. 22, 35 (1970).
Properties: Crystals. Bitter taste, followed by a sense of numbness. Stable in air at ordinary temps. Dec 195-200°. Sol in alcohol. Slightly sol in water (1:100), acetone and ethyl acetate. The aq soln is faintly acid to litmus. Extemporaneously prepd aq solns should be used promptly to avoid precipitation of the free base by traces of alkali. The soly in water is increased by the addn of sodium chloride. Insol in benzene or ether.
Therap-Cat: Anesthetic (local).
Keywords: Anesthetic (Local).
 
 
Status: This monograph has been retired and is no longer subject to revision or update.