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CAS No 53648-05-8 , N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide

  • Name: N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide
  • Synonyms: Ibuproxamum;N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide; BRN 2267673; n-hydroxy-2-(4-isobutylphenyl)propanamide; D,L-2-(4-Isobutylphenyl)propiohydroxamic acid; G-277; Ibudros;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.058g/cm3
  • Refractive index: 1.527
  • Flash Point: °C
  • EINECS: 258-683-8
  • Molecular Weight: 221.29546
  • InchiKey: BYPIURIATSUHDW-UHFFFAOYSA-N
  • InChI: InChI=1S/C13H19NO2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(15)14-16/h4-7,9-10,
    16H,8H2,1-3H3,(H,14,15)
  • Molecular Formula: C13H19NO2
  • Molecular Structure:CAS No:53648-05-8 N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide

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References of N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide
Title: Ibuproxam
CAS Registry Number: 53648-05-8
CAS Name: N-Hydroxy-a-methyl-4-(2-methylpropyl)benzeneacetamide
Synonyms: dl-2-(4-isobutylphenyl)propionohydroxamic acid
Manufacturers' Codes: G-277
Trademarks: Ibudros (Manetti Roberts)
Molecular Formula: C13H19NO2
Molecular Weight: 221.30
Percent Composition: C 70.56%, H 8.65%, N 6.33%, O 14.46%
Literature References: Hydroxylamine deriv of ibuprofen, q.v., to which it is converted in vivo. Prepn: G. Orzalesi, R. Selleri, DE 2400531; eidem, US 4082707 (1974, 1978 both to Manetti & Roberts). Metabolism in rats: G. Orzalesi et al., Arzneim.-Forsch. 27, 1012 (1977); in humans: eidem, ibid. 30, 1607 (1980). Pharmacological study: eidem, ibid. 27, 1006 (1977). Thermal decomposition: S. Chimichi et al., J. Pharm. Sci. 69, 521 (1980). Physico-chemical properties: M. Mannelli et al., Boll. Chim. Farm. 119, 203 (1980).
Properties: Crystals from acetone/petr ether, mp 119-121°. Sol in methanol, ethanol, acetone, ethyl ether. Practically insol in water and petr ether. LD50 in mice, rats (g/kg): >2, >3 orally (Orzalesi, Selleri, 1978).
Melting point: mp 119-121°
Toxicity data: LD50 in mice, rats (g/kg): >2, >3 orally (Orzalesi, Selleri, 1978)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives.