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CAS No 53-89-4 , 4-benzyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one

  • Name: 4-benzyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one
  • Synonyms: Telon;Benzpiperilone; Reubenil; BENZPIPERYLON; Humedil; Benzpiperylone; Reublonil;4-benzyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one; KB 95; Benzometan; PPBP;
  • CAS Registry Number:
  • Flash Point: 256.5°C
  • Boiling Point: 500.5°C at 760 mmHg
  • Density: 1.176g/cm3
  • Refractive index: 1.618
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 256.5°C
  • EINECS: 200-187-0
  • Molecular Weight: 347.4534
  • InchiKey: KMGARVOVYXNAOF-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H25N3O/c1-24-14-12-19(13-15-24)25-22(26)20(16-17-8-4-2-5-9-
    17)21(23-25)18-10-6-3-7-11-18/h2-11,19,23H,12-16H2,1H3
  • Molecular Formula: C22H25N3O
  • Molecular Structure:CAS No:53-89-4 4-benzyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one

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53-89-4 Benzpiperylone

  • Benzpiperylone, Min 99%
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References of 4-benzyl-2-(1-methylpiperidin-4-yl)-5-phenyl-1H-pyrazol-3-one
Title: Benzpiperylon
CAS Registry Number: 53-89-4
CAS Name: 1,2-Dihydro-2-(1-methyl-4-piperidinyl)-5-phenyl-4-(phenylmethyl)-3H-pyrazol-3-one
Synonyms: 4-benzyl-1-(1-methyl-4-piperidyl)-3-phenyl-3-pyrazolin-5-one; 1-(N-methyl-4-piperidyl)-3-phenyl-4-benzyl-5-pyrazolone; benzpiperilone
Manufacturers' Codes: KB-95
Trademarks: Humedil (Cheminova); Telon (Novartis)
Molecular Formula: C22H25N3O
Molecular Weight: 347.45
Percent Composition: C 76.05%, H 7.25%, N 12.09%, O 4.60%
Literature References: Prepd from (N-methylpiperidyl)hydrazine and ethyl 2-benzyl-3-oxo-3-phenylpropionate: A. Ebn?ther et al., Helv. Chim. Acta 42, 1201 (1959); E. Jucker et al., CH 346885, CH 346886 (1960 both to Sandoz), C.A. 58, 5696a,b (1963). See also: eidem, US 2903460 (1959 to Sandoz). Pharmacological properties, toxicity: A. Cerletti et al., Boll. Chim. Farm. 102, 602 (1963).
Properties: Crystals from ethanol, dec 181-183°. pK1 6.73, pK2 9.13. LD50 in mice, rats, rabbits (mg/kg): 160, 160, 83 i.v.; 1880, 2700, 1700 orally (Cerletti).
pKa: pK1 6.73, pK2 9.13
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): 160, 160, 83 i.v.; 1880, 2700, 1700 orally (Cerletti)
Therap-Cat: Analgesic; anti-inflammatory.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Pyrazolones.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.