CAS No 53-18-9 , Yohimban-16-carboxylicacid,1-[2-(diethylamino)ethyl]-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-,methyl ester, (3b,16b,17a,18b,20a)-

Name: Yohimban-16-carboxylicacid,1-[2-(diethylamino)ethyl]-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-,methyl ester, (3b,16b,17a,18b,20a)-
Synonyms: N-Diethylaminoethylreserpine; NSC 369865; Reserpine, 1-[2-(diethylamino)ethyl]-(7CI); DL 152;Diethylaminoreserpine; Bietaserpine;Yohimban-16-carboxylicacid,1-[2-(diethylamino)ethyl]-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-,methyl ester, (3b,16b,17a,18b,20a)-; S 1210; Methyl 1a,2b,3a,4aa,5,7,8,13,13bb,14,14aa-dodecahydro-1-[2-(diethylamino)ethyl]-2,11-dimethoxy-3b-(3,4,5-trimethoxybenzoyloxy)benz[g]indolo[2,3-a]quinolizine-1b-carboxylate;3b,20a-Yohimban-16b-carboxylic acid, 1-[2-(diethylamino)ethyl]-18b-hydroxy-11,17a-dimethoxy-, methyl ester,3,4,5-trimethoxybenzoate (ester) (8CI); 1-[2-(Diethylamino)ethyl]reserpine;
CAS Registry Number:53-18-9
Flash Point: 409°C
Boiling Point: 752.6°Cat760mmHg
Density: 1.27g/cm³
Refractive index: 1.598
Safety Statements: An experimental teratogen. When heated to decomposition it emits toxic fumes of NO_x.
Flash Point: 409°C
EINECS: 200-165-0
Molecular Weight: 707.95
InChI: InChI=1/C39H53N3O9/c1-9-40(10-2)15-16-42-29-20-25(45-3)11-12-26(29)27-13-14-41-22-24-19-33(37(49-7)34(39(44)50-8)28(24)21-30(41)35(27)42)51-38(43)23-17-31(46-4)36(48-6)32(18-23)47-5/h11-12,17-18,20,24,28,30,33-34,37H,9-10,13-16,19,21-22H2,1-8H3
Molecular Formula: C39H53 N3 O9
Molecular Structure:

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           53-18-9 Bietaserpine
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           53-18-9 Yohimban-16-carboxylicacid,1-[2-(diethylamino)ethyl]-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-,methyl ester, (3b,16b,17a,18b,20a)-
           
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           53-18-9 BIETASERPINE
           
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References of Yohimban-16-carboxylicacid,1-[2-(diethylamino)ethyl]-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-,methyl ester, (3b,16b,17a,18b,20a)-

Title: Bietaserpine
CAS Registry Number: 53-18-9
CAS Name: (3b,16b,17a,18b,20a)-1-[2-(Diethylamino)ethyl]-11,17-dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
Synonyms: 1-[2-(diethylamino)ethyl]-18b-hydroxy-11,17a-dimethoxy-3b,20a-yohimban-16b-carboxylic acid methyl ester, 3,4,5-trimethoxybenzoate ester; 1-[2-(diethylamino)ethyl]reserpine
Molecular Formula: C39H53N3O9
Molecular Weight: 707.85
Percent Composition: C 66.17%, H 7.55%, N 5.94%, O 20.34%
Literature References: Prepn: Buzas, Régnier, C.R. Hebd. Seances Acad. Sci. 250, 1340 (1960); Buzas et al., FR 1256524 (1961 to Dautreville & Lebas and Andre Buzas), C.A. 57, 2273e (1962); Buzas et al., FR M102 C.A. 58, 9159a (1963); GB 894866 (1961, 1962 both to Soc. Nogentaise de Prods. Chim. and Andre Buzas). Pharmacology: Garattini et al., J. Pharm. Pharmacol. 13, 548 (1961); Quevauviller et al., Therapie 18, 1429 (1963); Guerrin et al., C.R. Seances Soc. Biol. Ses Fil. 158, 1096 (1964); P. Berthaux, M. Neuman, Arzneim.-Forsch. 14, 1040 (1964).
Properties: Free base, [a]D17 -121° (c = 2 in CHCl3). Sol in dil acids and the usual organic solvents except cyclohexane and petr ether.
Optical Rotation: [a]D17 -121° (c = 2 in CHCl3)

Derivative Type: Bitartrate
CAS Registry Number: 1111-44-0
Manufacturers' Codes: DL-152
Trademarks: Tensibar (Clin-Comar-Byla)
Molecular Formula: C39H53N3O9.C4H6O6
Molecular Weight: 857.94
Percent Composition: C 60.20%, H 6.93%, N 4.90%, O 27.97%
Properties: Dec 145-150°. LD50 in mice (mg/kg): 620 orally; 430 i.p.; 215 i.v. (Berthaux, Neuman).
Toxicity data: LD50 in mice (mg/kg): 620 orally; 430 i.p.; 215 i.v. (Berthaux, Neuman)

Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Reserpine Derivatives.

Status: This monograph has been retired and is no longer subject to revision or update.