References of (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,
16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol
Title: Lynestrenol
CAS Registry Number: 52-76-6
CAS Name: (17a)-19-Norpregn-4-en-20-yn-17-ol
Synonyms: 17a-ethinyl-17b-hydroxyestr-4-ene; 17a-ethynylestr-4-en-17b-ol; 3-desoxynorlutin; ethinylestrenol
Trademarks: Exluton(a) (Organon); Exlutena (Organon); Orgametril (Organon); Orgametil
Molecular Formula: C20H28O
Molecular Weight: 284.44
Percent Composition: C 84.45%, H 9.92%, O 5.62%
Literature References: Prepn: de Winter
et al., Chem. Ind. (London) 1959, 905. Metabolism: Kamyab
et al., Biochem. J. 103, 14P (1967);
J. Endocrinol. 42, 337 (1968). Pharmacokinetics and metabolism: H. Kuhl
et al., Contraception 26, 303 (1982). Clinical trial of use in normophasic oral contraceptives: N. Dombrowicz
et al., ibid. 22, 537 (1980). Review of carcinogenicity studies:
IARC Monographs 21, 407-415 (1979).
Properties: Solid, mp 158-160°. [a]D -13° (chloroform).
Melting point: mp 158-160°
Optical Rotation: [a]D -13° (chloroform)
Derivative Type: Mixture with ethinyl estradiol
CAS Registry Number: 8064-76-4
Trademarks: Fysionorm (Nourypharma); Minilyn (Organon); Ovanon (Nourypharma); Ovoresta (Organon); Yermonil (Novartis)
Derivative Type: Mixture with mestranol
CAS Registry Number: 8015-14-3
Trademarks: Lyndiol (Organon)
Therap-Cat: Progestogen. In combination with estrogen as oral contraceptive.
Keywords: Contraceptive (Oral); Progestogen.
![CAS No:52-76-6 (8R,9S,10R,13S,14S,17R)-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,<br />16-dodecahydro-1H-cyclopenta[a]phenanthren-17-ol](/structure/cas-52/52-76-6.png)
