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CAS No 52-24-4 , tris(aziridin-1-yl)-sulfanylidene-λ Search by region : China

  • Name: tris(aziridin-1-yl)-sulfanylidene-λ
  • Synonyms: Triethylenethiophosphoramide;tris(aziridin-1-yl)-sulfanylidene-λ Tiofozil;5-phosphane; Tiofosyl; Girostan; Tespamin; Tiofosfamid; Thiophosphamide; Thiofozil;THIO-TEPA;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 54-57 ºC
  • Flash Point: 117.2°C
  • Boiling Point: 270.2°Cat760mmHg
  • Density: 1.5g/cm3
  • Refractive index: 1.708
  • Water Solubility: 19 G/100 ML (25 ºC)
  • Safety Statements: R28;R45;R46
  • Hazard Symbols: T+: Very toxic;
  • Flash Point: 117.2°C
  • EINECS: 200-135-7
  • Molecular Weight: 189.218342
  • InchiKey: FOCVUCIESVLUNU-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2
  • Risk Statements: S28;S36/37;S45;S53
  • Molecular Formula: C6H12N3PS
  • Molecular Structure:CAS No:52-24-4 tris(aziridin-1-yl)-sulfanylidene-λ

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References of tris(aziridin-1-yl)-sulfanylidene-λ
Title: Triethylenethiophosphoramide
CAS Registry Number: 52-24-4
CAS Name: 1,1￠,1￠￠-Phosphinothioylidynetrisaziridine
Synonyms: tris(1-aziridinyl)phosphine sulfide; thiotepa
Trademarks: Tespamin (Sumitomo); Tifosyl (Astra)
Molecular Formula: C6H12N3PS
Molecular Weight: 189.22
Percent Composition: C 38.08%, H 6.39%, N 22.21%, P 16.37%, S 16.95%
Literature References: Preparation: Kuh, Seeger, US 2670347 (1954 to Am. Cyanamid); Saijo, Endo, JP 55 218 (1955 to Semimoto Chem.). Toxicity data: Scherf et al., Arzneim.-Forsch. 20, 1467 (1970). Review of carcinogenicity studies: IARC Monographs 9, 85-94 (1975).
Properties: Crystals from pentane or ether, mp 51.5°. Soly in water at 25°: 19 g/100 ml. Freely sol in alc; sol in benzene, ether, chloroform. LD50 i.v. in rats: 15 mg/kg (Scherf).
Melting point: mp 51.5°
Toxicity data: LD50 i.v. in rats: 15 mg/kg (Scherf)
CAUTION: This substance is listed as a known human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-249.
Use: Insect sterilant.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents; Ethylenimines and Methylmelamines.