Home > Name List By s > S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9, 11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene...

CAS No 52-01-7 , S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,
11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,
2'-oxolane]-7-yl] ethanethioate

  • Name: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,
    11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,
    2'-oxolane]-7-yl] ethanethioate
  • Synonyms: S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,
    11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,
    2'-oxolane]-7-yl] ethanethioate; Spirolactone; Euteberol; Aldactone A; Spiroctan; Verospirone; Spironocompren;Aldactone; Spirolang; Verospiron;
  • CAS Registry Number:
  • Melting Point: 198-207 ºC (DEC.)
  • Flash Point: 302.3°C
  • Boiling Point: 597°Cat760mmHg
  • Density: 1.24g/cm3
  • Refractive index: -36 ° (C=1, CHCl3)
  • Alpha: -37 º (C=1, CHCL3)
  • Safety Statements: R40;R60
  • Hazard Symbols: Xn: Harmful;T: Toxic;
  • Flash Point: 302.3°C
  • EINECS: 200-133-6
  • Molecular Weight: 416.57348
  • InchiKey: LXMSZDCAJNLERA-ZHYRCANASA-N
  • InChI: InChI=1S/C24H32O4S/c1-14(25)29-19-13-15-12-16(26)4-8-22(15,
    2)17-5-9-23(3)18(21(17)19)6-10-24(23)11-7-20(27)28-24/h12,17-19,21H,
    4-11,13H2,1-3H3/t17-,18-,19+,21+,22-,23-,24+/m0/s1
  • Risk Statements: S53;S22;S36/37/39;S45
  • Molecular Formula: C24H32O4S
  • Molecular Structure:CAS No:52-01-7 S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,<br />11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,<br />2'-oxolane]-7-yl] ethanethioate

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References of S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,
11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,
2'-oxolane]-7-yl] ethanethioate
Title: Spironolactone
CAS Registry Number: 52-01-7
CAS Name: (7a,17a)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid g-lactone
Synonyms: 17-hydroxy-7a-mercapto-3-oxo-17a-pregn-4-ene-21-carboxylic acid g-lactone, acetate; 3-(3-oxo-7a-acetylthio-17b-hydroxy-4-androsten-17a-yl)propionic acid g-lactone
Manufacturers' Codes: SC-9420
Trademarks: Aldactone (Pharmacia & Upjohn); Aquareduct (Azupharma); Practon (Pfizer); Osyrol (Aventis); Sincomen (Schering AG); Spirobeta (Betapharm); Spiroctan (Ferlux); Spirolone (APS); Spironone (Dexo); Verospiron (Richter Gedeon); Xenalon (Mepha)
Molecular Formula: C24H32O4S
Molecular Weight: 416.57
Percent Composition: C 69.20%, H 7.74%, O 15.36%, S 7.70%
Literature References: Aldosterone antagonist. Prepn: Cella, Tweit, J. Org. Chem. 24, 1109 (1959); US 3013012 (1961 to Searle); Tweit et al., J. Org. Chem. 27, 3325 (1962). Activity and metabolic studies: Gerhards, Engelhardt, Arzneim.-Forsch. 13, 972 (1963). Crystal and molecular structure: Dideberg, Dupont, Acta Crystallogr. B28, 3014 (1972). Comprehensive description: J. L. Sutter, E. P. K. Lau, Anal. Profiles Drug Subs. 4, 431-451 (1975). Review of carcinogenetic risk: IARC Monographs 24, 259-273 (1980). Review of antiandrogen effects and clinical use in hirsutism: R. R. Tremblay, Clin. Endocrinol. Metab. 15, 363-371 (1986); of clinical efficacy in hypertension: A. N. Brest, Clin. Ther. 8, 568-585 (1986). Review of pharmacology: H. A. Skluth, J. G. Gums, DICP Ann. Pharmacother. 24, 52-59 (1990). Clinical trial in congestive heart failure: B. Pitt et al., N. Engl. J. Med. 341, 709 (1999).
Properties: Crystals from methanol, mp 134-135° (resolidifies and dec 201-202°). [a]D20 -33.5° (chloroform). uv max: 238 nm (e 20200). Practically insol in water. Sol in alcohol; freely sol in benzene, chloroform. LD50 in rats, mice, rabbits (mg/kg): 790, 360, 870 i.p. (IARC, 1980).
Melting point: mp 134-135° (resolidifies and dec 201-202°)
Optical Rotation: [a]D20 -33.5° (chloroform)
Absorption maximum: uv max: 238 nm (e 20200)
Toxicity data: LD50 in rats, mice, rabbits (mg/kg): 790, 360, 870 i.p. (IARC, 1980)
Therap-Cat: Diuretic.
Therap-Cat-Vet: Diuretic.
Keywords: Aldosterone Antagonist; Diuretic; Steroids.