Home > Name List By 8 > 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid

CAS No 51940-44-4 , 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid

  • Name: 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid
  • Synonyms: 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid; Acide pipemidique; 51940-44-4; piperamic acid; Acido pipemidico; Palin; Pipedac; Acidum pipemidicum; Pipram;Deblaston;
  • CAS Registry Number:
  • Transport: 25kgs
  • Flash Point: 277.3°C
  • Boiling Point: 534.9°Cat760mmHg
  • Density: 1.38g/cm3
  • Refractive index: 1.617
  • Water Solubility: Insoluble
  • Hazard Symbols: UN NO.
  • Flash Point: 277.3°C
  • EINECS: 257-530-2
  • Molecular Weight: 303.31648
  • InchiKey: JOHZPMXAZQZXHR-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H17N5O3/c1-2-18-8-10(13(21)22)11(20)9-7-16-14(17-12(9)18)19-
    5-3-15-4-6-19/h7-8,15H,2-6H2,1H3,(H,21,22)
  • Molecular Formula: C14H17N5O3
  • Molecular Structure:CAS No:51940-44-4 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid

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References of 8-ethyl-5-oxo-2-piperazin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid
Title: Pipemidic Acid
CAS Registry Number: 51940-44-4
CAS Name: 8-Ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)pyrido[2,3-d]pyrimidine-6-carboxylic acid
Synonyms: piperamic acid
Manufacturers' Codes: 1489-RB
Trademarks: Filtrax (Biomed. Foscama); Memento 400 (Volpino); Pi-Coli (Ist. Vitamine); Pipeacid (SIT); Pipedac (Teofarma); Pipemid (Gentili); Pipurin (Brocchieri); Tractur (Damor); Uropimid (CT); Urosten (Bonomelli); Uroval (Firma)
Molecular Formula: C14H17N5O3
Molecular Weight: 303.32
Percent Composition: C 55.44%, H 5.65%, N 23.09%, O 15.82%
Literature References: Quinolone antibacterial. Prepn: S. Minami et al., DE 2341146; eidem, US 3887557 (1974, 1975 both to Dainippon Pharm.); Pesson et al., C.R. Seances Acad. Sci. Ser. C 278, 1169 (1974); De Lajudie et al., ibid. Ser. D 279, 1931 (1974); Matsumoto, Minami, J. Med. Chem. 18, 74 (1975). Characterization: Ficicchia, Farmaco Ed. Prat. 30, 207 (1974). Antibacterial activity: Ficicchia, De Lajudie, ibid. 252. Pharmacology: Shimizu et al., Antimicrob. Agents Chemother. 7, 441 (1975).
Properties: Yellowish-white, odorless, bitter-tasting crystals, mp 253-255°. Hygroscopic. Yellows slowly in light. Sol in acid soln and alkaline. Very slightly sol in water, alcohol; slightly sol in chloroform (0.5%), methanol (0.4%). Practically insol in ether, benzene. LD50 in mice (mg/kg): 4000 orally; 1000 i.p., 50 i.v. (Ficicchia).
Melting point: mp 253-255°
Toxicity data: LD50 in mice (mg/kg): 4000 orally; 1000 i.p., 50 i.v. (Ficicchia)
 
Derivative Type: Trihydrate
CAS Registry Number: 72571-82-5
Trademarks: Deblaston (Madaus); Dolcol (Dainippon); Pipram (RPR); Solupemid (Recordati)
Properties: Nearly colorless needles, mp 253-255°.
Melting point: mp 253-255°
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.