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CAS No 519-23-3 , 5,11-dimethyl-6H-pyrido[4,3-b]carbazole Search by region : Switzerland

  • Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazole
  • Synonyms: NSC 71795;Elliptisine; NSC71795; 519-23-3;5,11-dimethyl-6H-pyrido[4,3-b]carbazole; NSC-71795; MLS000736786; TCMDC-125546; 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole;
  • CAS Registry Number:
  • Transport: UN 3462 6.1/PG 3
  • Melting Point: 316-318°C
  • Flash Point: 227.1°C
  • Boiling Point: 495.4°Cat760mmHg
  • Density: 1.257g/cm3
  • Refractive index: 1.777
  • Safety Statements: Poison by ingestion, intravenous, and intraperitoneal routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: T
  • Flash Point: 227.1°C
  • EINECS: 208-264-0
  • Molecular Weight: 246.30646
  • InchiKey: CTSPAMFJBXKSOY-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15
    (13)19-17/h3-9,19H,1-2H3
  • Risk Statements: 25
  • Molecular Formula: C17H14N2
  • Molecular Structure:CAS No:519-23-3 5,11-dimethyl-6H-pyrido[4,3-b]carbazole

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519-23-3 ELLIPTICINE

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References of 5,11-dimethyl-6H-pyrido[4,3-b]carbazole
Title: Ellipticine
CAS Registry Number: 519-23-3
CAS Name: 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole
Molecular Formula: C17H14N2
Molecular Weight: 246.31
Percent Composition: C 82.90%, H 5.73%, N 11.37%
Literature References: Antitumor alkaloid isolated from Ochrosia elliptica Labill., O. sandwicensis A. DC., O. viellardii, O. silvatica, Apocynaceae: Goodwin et al., J. Am. Chem. Soc. 81, 1903 (1959); Kan Fan et al., Phytochemistry 9, 1351 (1970); Cosson, Schmid, ibid. 1353. Structure and synthesis: Woodward et al., J. Am. Chem. Soc. 81, 4434 (1959). Syntheses: J. Bergman, R. Carlsson, Tetrahedron Lett. 1977, 4663; D. A. Taylor et al., J. Chem. Res. Miniprint 1979, 4801; S. Kano et al., J. Org. Chem. 46, 2979 (1981); R. Besselievre, H. P. Husson, Tetrahedron 37, 241 (1981). Regioselective synthesis: T.-L. Ho, S.-Y. Hsieh, Helv. Chim. Acta 89, 111 (2006). Toxicity study: Rakieten et al., U.S. Gov. Res. Dev. Rep. 67, 38 (1967), C.A. 68, 20827g (1968). Review of syntheses: M. Sainsbury, Synthesis 1977, 437-448; R. Barone, M. Chanon, Heterocycles 16, 1357-1365 (1981). Review of antineoplastic activity: K. W. Kohn et al., Antibiotics vol. 5 (pt. 2), F. E. Hahn, Ed. (Springer-Verlag, New York, 1979) pp 195-213.
Properties: Bright yellow needles from ethyl acetate, mp 311-315° (dec). uv max: 239, 277, 286, 294, 332, 382, 400 nm (log e 4.23, 4.61, 4.76, 4.74, 3.65, 3.61, 3.53). LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten).
Melting point: mp 311-315° (dec)
Absorption maximum: uv max: 239, 277, 286, 294, 332, 382, 400 nm (log e 4.23, 4.61, 4.76, 4.74, 3.65, 3.61, 3.53)
Toxicity data: LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten)