CAS No 51803-78-2 , N-(4-nitro-2-phenoxyphenyl)methanesulfonamide Search by region : Canada

Name: N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
Synonyms: Antifloxil; 51803-78-2; Guaxan; Nimed;N-(4-nitro-2-phenoxyphenyl)methanesulfonamide; N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide;Mesulid; Flogovital; Sulidene;
CAS Registry Number:51803-78-2
Transport: UN 2811 6
Melting Point: 140-146 ºC
Flash Point: 221.1ºC
Boiling Point: 442 ºC at 760 mmHg
Density: 1.451 g/cm³
Water Solubility: Stable. Incompatible with strong oxidizing agents.
Safety Statements: 36-26
Hazard Symbols: Xn: Harmful;Xi: Irritant;
Flash Point: 221.1ºC
EINECS: 257-431-4
Molecular Weight: 308.30978
InchiKey: HYWYRSMBCFDLJT-UHFFFAOYSA-N
InChI: InChI=1S/C13H12N2O5S/c1-21(18,
19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3
Risk Statements: 22-36/37/38
Molecular Formula: C₁₃H₁₂N₂O₅S
Molecular Structure:

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           51803-78-2 nimesulide
           
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             TLC PharmaChem., Inc.
             
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References of N-(4-nitro-2-phenoxyphenyl)methanesulfonamide

Title: Nimesulide
CAS Registry Number: 51803-78-2
CAS Name: N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
Synonyms: 4-nitro-2-phenoxymethanesulfonanilide
Manufacturers' Codes: R-805
Trademarks: Aulin (Boehringer, Mann.); Fansidol (Brocchieri); Flogovital (Bago); Mesulid (LPB); Nide (Ibirn); Nidol (Tosi); Nisulid (Wyeth)
Molecular Formula: C13H12N2O5S
Molecular Weight: 308.31
Percent Composition: C 50.64%, H 3.92%, N 9.09%, O 25.95%, S 10.40%
Literature References: Prostaglandin synthetase and platelet aggregation inhibitor. Prepn and anti-inflammatory activity: BE 801812; G. G. I. Moore, J. K. Harrington, US 3840597 (both 1974 to Riker). Activity, comparison with other non-steroidal anti-inflammatories: K. F. Swingle et al., Arch. Int. Pharmacodyn. Ther. 221, 132 (1976). Mechanism of action: R. L. Vigdahl, R. H. Tukey, Biochem. Pharmacol. 26, 307 (1977). Chromatographic determn in plasma: S. F. Chang et al., J. Pharm. Sci. 66, 1700 (1977). Pharmacology: K. F. Swingle, G. G. I. Moore, Drugs Exp. Clin. Res. 10, 587 (1984). Clinical trials in rheumatic disorders: R. Weissenbach, J. Int. Med. Res. 9, 349 (1981); in osteoarthritis: M. Reiner, ibid. 10, 92 (1982); in acute inflammation: J. M. Pais, F. M. Rosteiro, ibid. 11, 149 (1983); C. Milvio, ibid. 12, 327 (1984); M. E. Nouri, Clin. Ther. 6, 142 (1984).
Properties: Light tan crystals from ethanol, mp 143-144.5°. LD50 orally in rats: 324 mg/kg (Swingle, Moore).
Melting point: mp 143-144.5°
Toxicity data: LD50 orally in rats: 324 mg/kg (Swingle, Moore)
Therap-Cat: Anti-inflammatory.
Therap-Cat-Vet: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal).