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CAS No 51627-14-6 , Cefatrizine

  • Name: Cefatrizine
  • Synonyms: CEFATRIZINE; antibioticbl-640; Cephathiamidine;7-[2-(4-Hydroxyphenyl)-2-aminoacetamido]-3-(1,2,3-triazole-4-ylthio)methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 7-[2-(4-hydroxyphenyl)-2-aminoacetamido]-3-(1,2,3-triazole-4-ylthio)methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; eta(r)))-; s640p;Cefatrizine; antibioticbl-s640; cephatriazine; bls640;eta(r)))- l)acetyl)amino)-8-oxo-3-((1h-1,2,3-triazol-4-ylthio)methyl)-,(6r-(6-alpha,7-b;
  • CAS Registry Number:
  • Transport: 5kgs
  • Flash Point: 527.2°C
  • Boiling Point: 948.1°Cat760mmHg
  • Density: 1.73g/cm3
  • Refractive index: 1.793
  • Hazard Symbols: UN NO.
  • Flash Point: 527.2°C
  • EINECS: 257-324-2
  • Molecular Weight: 462.50
  • InChI: InChI=1/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12?,13-,17-/m1/s1
  • Molecular Formula: C18H18N6O5S2
  • Molecular Structure:CAS No:51627-14-6 Cefatrizine

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References of Cefatrizine
Title: Cefatrizine
CAS Registry Number: 51627-14-6
CAS Name: (6R,7R)-7-[[(2R)-Amino-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-[(1H-1,2,3-triazol-4-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms: 7-[D-a-amino-a-(4-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-4(5)-ylthiomethyl)-3-cephem-4-carboxylic acid
Manufacturers' Codes: BL-S640; SKF-60771; S-640P
Trademarks: Cefaperos (Allard)
Molecular Formula: C18H18N6O5S2
Molecular Weight: 462.50
Percent Composition: C 46.74%, H 3.92%, N 18.17%, O 17.30%, S 13.87%
Literature References: Orally active semi-synthetic cephalosporin antibiotic. Prepn: G. L. Dunn, J. R. E. Hoover, DE 2316866; eidem, US 3867380 (1974, 1975 both to SK&F); D. Willner, L. B. Crast, DE 2364192 (1974 to Bristol-Myers), C.A. 81, 105538 (1974); G. L. Dunn et al., J. Antibiot. 29, 65 (1976). Prepn of the propylene glycolate: M. A. Kaplan, A. P. Granatek, DE 2500385; eidem, US 3970651 (1975, 1976 both to Bristol-Myers). In vitro and in vivo antibacterial activity and pharmacokinetic behavior: P. Actor et al., ibid. 28, 594 (1975); F. Leitner et al., Antimicrob. Agents Chemother. 7, 298 (1975). General pharmacological properties: M. Matsuzaki et al., Jpn. J. Antibiot. 29, 107 (1976), C.A. 85, 311g (1976). Determn in serum and urine by HPLC: E. Crombez et al., J. Chromatogr. 173, 165 (1979). Disposition of 14C-cefatrizine in man: R. C. Gaver, G. Deeb, Drug Metab. Dispos. 8, 157 (1980). Activity and clinical use: A. J. Weinstein, Drugs 20, 137 (1980). Acute toxicity: M. Matsuzaki et al., Jpn. J. Antibiot. 29, 612 (1976), C.A. 85, 171724y (1976). Toxicological studies: ibid. 639-686, C.A. 85, 171722w-171723x (1976). Series of articles on pharmacokinetics and clinical efficacy: Drugs Exp. Clin. Res. 11, 441-462 (1985).
Properties: Zwitterionic. LD50 in male, female mice, male, female rats (mg/kg): 6880, 6410, 4325, 4325 i.p. (Matsuzaki).
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 6880, 6410, 4325, 4325 i.p. (Matsuzaki)
 
Derivative Type: Compd with propylene glycol
CAS Registry Number: 64217-62-5
Trademarks: Bricef (BMS); Cepticol (Banyu); Cefotrizin (Firma); Faretrizin (Lafare); Kefoxina (CT); Tamyl (Italchimici); Zitrix (Metapharma)
Molecular Formula: C18H18N6O5S2.C3H8O2
Molecular Weight: 538.60
Percent Composition: C 46.83%, H 4.87%, N 15.60%, O 20.79%, S 11.91%
Properties: Rod-like crystals. [a]D23 +55.9° (c = 1% in 1N HCl). uv max: 227, 272 nm.
Optical Rotation: [a]D23 +55.9° (c = 1% in 1N HCl)
Absorption maximum: uv max: 227, 272 nm
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.