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CAS No 50-78-2 , 2-acetyloxybenzoic acid

  • Name: 2-acetyloxybenzoic acid
  • Synonyms: Acetosal; Acylpyrin;2-acetyloxybenzoic acid; Polopiryna; Ecotrin; Acenterine; Colfarit; 2-Acetoxybenzoic acid;ACETYLSALICYLIC ACID;
  • CAS Registry Number:
  • Transport: UN 1851
  • Melting Point: 136-140 ºC
  • Flash Point: 250 ºC
  • Boiling Point: 140 C
  • Density: 1.35
  • Water Solubility: 3.3 G/L (20 ºC)
  • Safety Statements: R22;R36/37/38
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 250 ºC
  • EINECS: 200-064-1
  • Molecular Weight: 180.15742
  • InchiKey: BSYNRYMUTXBXSQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
  • Risk Statements: S26;S36/37/39
  • Molecular Formula: C9H8O4
  • Molecular Structure:CAS No:50-78-2 2-acetyloxybenzoic acid
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50-78-2 ACETYLSALICYLIC ACID

  • China Dragon Chemical Group Co.,China null
  • Fax: +86-571-88391332 49-211-550203-10
  • Address: 10/Fl., Jinjiang Building, 111 South Hushu Rd., Hangzhou, China null,nullChina
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50-78-2 Aspirin

  • China CIDIC Co.,Ltd. null
  • Fax: +86-510-82303031
  • Address: 15/F, HODO International Plaza, 531 Zhongshan Road, Wuxi, China null,nullChina
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50-78-2 Aspirin

  • United States CBSCHEM LIMITED null
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 null,nullUnited States
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50-78-2 Acetylsalicylic acid

  • India Nile Chemicals [Manufacturers]
  • Tel: +91-(22)-66313162, 23454828
  • Fax: +91-(22)-23454828
  • Address: 202, Matruchhaya, 378/80 Narshi Natha Street, Mumbai, Maharashtra 400 009, Mumbai,MumbaiIndia
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50-78-2 Acetylsalicylic Acid

  • Acetylsalicylic Acid
  • United States LKT Laboratories, Inc [Manufacturer]
  • Tel: (888)-558-5227
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  • Address: 2233 University Ave. West 55114-1600 St. PaulUNITED STATES 55114-1600 St. Paul,nullUnited States
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50-78-2 Acetylsalicylic acid

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50-78-2 ACETYLSALYCILC ACID

  • United States Advanced Synthesis Technologies [Manufacturer]
  • Tel: 619-423-7821
  • Fax: 619-423-7793
  • Address: Advanced Synthesis
    P.O. Box 437920
    San Ysidro, CA 92173 null,nullUnited States
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50-78-2 ASPIRIN-D3

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. null,nullIndia
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50-78-2 ASPIRIN

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50-78-2 ASPIRIN

  • China NINGBO V&P CHEMISTRY [Manufacturer]
  • Tel: 86-574-27666767
  • Fax: 86-574-56704282
  • Address: 21/F, NO.11 BLDG,XIN TIAN DI,
    NO689, SHI JI ROAD,
    NINGBO,CHINA, 315040 null,nullChina
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References of 2-acetyloxybenzoic acid
Title: Aspirin
CAS Registry Number: 50-78-2
CAS Name: 2-(Acetyloxy)benzoic acid
Synonyms: salicylic acid acetate; 2-acetoxybenzoic acid; acetylsalicylic acid
Trademarks: Acylpyrin (Slovakofarma); Angettes (BMS); Asatard (Boehringer, Ing.); Aspro (Roche); Cardioaspirin (Bayer); Cardiprin (Reckitt Benckiser); Cemirit (Bayer); Claragine (Nicholas); Ecotrin (GSK); Empirin (GSK); Encaprin (Procter & Gamble); Rhonal (Aventis); Solprin (Reckitt Benckiser)
Molecular Formula: C9H8O4
Molecular Weight: 180.16
Percent Composition: C 60.00%, H 4.48%, O 35.52%
Literature References: Prepn: C. Gerhardt, Ann. 87, 149 (1853). Manuf from salicylic acid and acetic anhydride: Faith, Keyes & Clark's Industrial Chemicals, F. A. Lowenheim, M. K. Moran, Eds. (Wiley-Interscience, New York, 4th ed., 1975) pp 117-120. Crystallization from acetone: Hamer, Phillips, US 2890240 (1959 to Monsanto). Novel process involving distillation: Edmunds, US 3235583 (1966 to Norwich Pharm.). Crystal structure: P. J. Wheatley, J. Chem. Soc. (Suppl.) 1964, 6036. Characterization of a second polymorphic form: P. Vishweshwar et al., J. Am. Chem. Soc. 127, 16802 (2005). Toxicity data: E. R. Hart, J. Pharmacol. Exp. Ther. 89, 205 (1947). Evaluation as a risk factor in Reye's syndrome: P. J. Waldman et al., J. Am. Med. Assoc. 247, 3089 (1982). Review of clinical trials in prevention of myocardial infarction and stroke: P. C. Elwood, Drugs 28, 1-5 (1984). Symposium on aspirin therapy: Am. J. Med. 74, no. 6A, 1-109 (1983). Clinical trials in prevention of colorectal cancer: R. S. Sandler et al., N. Engl. J. Med. 348, 883 (2003); J. A. Baron et al., ibid. 891. Comprehensive description: K. Florey, Anal. Profiles Drug Subs. 8, 1-46 (1979). Monograph: M. J. H. Smith, P. K. Smith, The Salicylates (Interscience, New York, 1966) 313 pp. Book: Acetylsalicylic Acid, H. J. M. Barnett et al., Eds. (Raven, New York, 1982) 278 pp.
Properties: Monoclinic tablets or needle-like crystals. d 1.40. mp 135° (rapid heating); the melt solidifies at 118°. uv max (0.1N H2SO4): 229 nm (E1%1cm 484); (CHCl3): 277 nm (E1%1cm 68). Is odorless, but in moist air it is gradually hydrolyzed into salicylic and acetic acids and acquires the odor of acetic acid. Stable in dry air. pK (25°) 3.49. One gram dissolves in 300 ml water at 25°, in 100 ml water at 37°, in 5 ml alcohol, 17 ml chloroform, 10-15 ml ether. Less soluble in anhydr ether. Decomp by boiling water or when dissolved in solns of alkali hydroxides and carbonates. Inorganic salts of acetylsalicylic acid are soluble in water (esp the Ca salt, q.v.), but are decomposed quickly. LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart).
Melting point: mp 135° (rapid heating)
pKa: pK (25°) 3.49
Absorption maximum: uv max (0.1N H2SO4): 229 nm (E1%1cm 484); (CHCl3): 277 nm (E1%1cm 68)
Density: d 1.40
Toxicity data: LD50 orally in mice, rats: 1.1, 1.5 g/kg (Hart)
 
Derivative Type: Guaiacol ester
CAS Registry Number: 55482-89-8
Synonyms: Guacetisal
Trademarks: Guaiaspir (Lampugnani)
Molecular Formula: C16H14O5
Molecular Weight: 286.28
Percent Composition: C 67.13%, H 4.93%, O 27.94%
 
Derivative Type: Methyl ester see Methyl Acetylsalicylate
 
Derivative Type: Phenyl ester see Phenyl Acetylsalicylate
 
CAUTION: Potential symptoms of overexposure are increased blood clotting time; nausea, vomiting; liver, kidney injury. Direct contact may cause eye, skin and upper respiratory irritation. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 6.
Therap-Cat: Analgesic; antipyretic; anti-inflammatory; antithrombotic.
Therap-Cat-Vet: Analgesic; antipyretic; anti-inflammatory; antithrombotic.
Keywords: Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic; Antithrombotic.