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CAS No 50-76-0 , Actinomycin D

  • Name: Actinomycin D
  • Synonyms: Dilactone actinomycin D acid; Lyovac cosmegen; Actinomycin-[threo-val-pro-sar-meval]; Actinomycin 7; actinomyein-theo-val-pro-sar-meval; actinomycin x i; AD; 2-Amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide; Cosmegen;Dactinomycin; Actinomycin AIV; X 97; actinomycin cl; Actinomycin I1; C1; Actinomycin X 1;Actinomycin D; actinomycin i; (-)-actinomycin d; Meractinomycin; Actinomycindioic D acid, dilactone; Actinomycin C1; dactinomyein d; Dactinomycin D; Dilactone actinomycindioic D acid; Actactinomycin A IV; ACT;3H-Phenoxazine-1,9-dicarboxamide, 2-amino-N,N'-bis[hexadecahydro-2,5,9-trimethyl-6,13-bis(1-methylethyl)-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-; ACTO-D; Oncostatin K; Actinomycin D; Actinomycin IV; hbf 386;
  • CAS Registry Number:
  • Transport: UN 3462 6
  • Melting Point: 241-243 ºC
  • Density: 1.42 g/cm3
  • Refractive index: 1.656
  • Safety Statements: R28;R40;R61
  • Hazard Symbols: T+: Very toxic;
  • EINECS: 200-063-6
  • Molecular Weight: 1255.43
  • InChI: InChI=1/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)
  • Risk Statements: S1;S45
  • Molecular Formula: C62H86N12O16
  • Molecular Structure:CAS No:50-76-0 Actinomycin D

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References of Actinomycin D
Title: Dactinomycin
CAS Registry Number: 50-76-0
CAS Name: Actinomycin D
Synonyms: actinomycin-[thr-val-pro-sar-meval]; meractinomycin; actinomycin AIV; actinomycin IV; actinomycin C1; actinomycin I1; actinomycin X1
Manufacturers' Codes: NSC-3053
Trademarks: Cosmegen (Merck & Co.)
Molecular Formula: C62H86N12O16
Molecular Weight: 1255.42
Percent Composition: C 59.32%, H 6.90%, N 13.39%, O 20.39%
Literature References: Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Historical background of actinomycins and chemistry, toxicology, pharmacology of actinomycin D: Ann. N.Y. Acad. Sci. 89, 285-485 (1960). Isoln from broth cultures of S. parvulus: Manaker et al., Antibiot. Ann. 1954/55, 853. Structure: Bullock, Johnson, J. Chem. Soc. 1957, 3280. Synthesis: Brockmann, Manegold, Naturwissenschaften 51, 383 (1964); Brockmann, Lackner, ibid. 384, 435 (1964); Brockmann et al., DE 1172680 (1964 to Bayer); eidem, Ber. 101, 1312 (1968); Meienhofer, J. Am. Chem. Soc. 92, 3771 (1970); T. Tanaka et al., Bull. Chem. Soc. Jpn. 53, 1352 (1980); K. Nakajima et al., Pept. Chem. 19, 143-148 (1981). Conformation from NMR: Conti, DeSantis, Nature 227, 1239 (1970); Lackner, Ber. 104, 3653 (1971). Toxicity data: F. S. Philips et al., Ann. N.Y. Acad. Sci. 89, 348 (1960). Review and evaluation of studies of carcinogenic action in laboratory animals: IARC Monographs 12, 29-41 (1976).
 
Derivative Type: Trihydrate
Properties: Bright red, rhomboid prisms from abs alc, dec 241.5-243°. [a]D28 -315° (c = 0.25 in methanol). Abs max (methanol): 244, 441 nm (A1%1cm 281, 206). Dil solns are very sensitive to light. Sol in alc, propylene glycol, water + glycol mixtures. LD50 orally in mice, rats: 13.0, 7.2 mg/kg (Philips).
Optical Rotation: [a]D28 -315° (c = 0.25 in methanol)
Absorption maximum: Abs max (methanol): 244, 441 nm (A1%1cm 281, 206)
Toxicity data: LD50 orally in mice, rats: 13.0, 7.2 mg/kg (Philips)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs; Actinomycins.