Title: Lypressin
CAS Registry Number: 50-57-7
CAS Name: 8-L-Lysinevasopressin
Synonyms: Schweine-Vasopressin; Phe3-Lys8-oxytocin
Trademarks: Diapid (Sandoz); Postacton; Syntopressin (Sandoz)
Molecular Formula: C46H65N13O12S2
Molecular Weight: 1056.22
Percent Composition: C 52.31%, H 6.20%, N 17.24%, O 18.18%, S 6.07%
Literature References: Purification after isolation from hog pituitary glands: Ward, du Vigneaud,
J. Biol. Chem. 222, 951 (1956). Structure: du Vigneaud
et al., J. Am. Chem. Soc. 75, 4880 (1953); Bartlett
et al., ibid. 78, 2905 (1956). Synthesis: du Vigneaud
et al., loc. cit.; Bartlett
et al., loc. cit.; Bodanszky
et al., ibid. 82, 3195 (1960); Boissonnas, Huguenin,
Helv. Chim. Acta 43, 182 (1960); Zaoral,
Collect. Czech. Chem. Commun. 30, 1853 (1965); Meienhofer, Sano,
J. Am. Chem. Soc. 90, 2996 (1968); Meienhofer, Trzeciak,
Proc. Natl. Acad. Sci. USA 68, 1006 (1971). Configuration: Schally, Barret,
J. Am. Chem. Soc. 87, 2497 (1965).
Review: E. Schr?der, K. Lübke,
The Peptides vol. II (Academic Press, New York, 1966) pp 336-350.
Therap-Cat: Antidiuretic; vasopressor.
Keywords: Antidiuretic.
